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Elisabeth Simader
Researcher at Medical University of Vienna
Publications - 33
Citations - 414
Elisabeth Simader is an academic researcher from Medical University of Vienna. The author has contributed to research in topics: Medicine & Vaccination. The author has an hindex of 8, co-authored 20 publications receiving 229 citations.
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Journal ArticleDOI
Analysis of the Secretome of Apoptotic Peripheral Blood Mononuclear Cells: Impact of Released Proteins and Exosomes for Tissue Regeneration.
Lucian Beer,Matthias Zimmermann,Andreas Mitterbauer,Adolf Ellinger,Florian Gruber,Marie-Sophie Narzt,Maria Zellner,Mariann Gyöngyösi,Sibylle Madlener,Elisabeth Simader,Christian Gabriel,Michael Mildner,Hendrik Jan Ankersmit +12 more
TL;DR: The results indicate that irradiation modulates the release of proteins, lipid-mediators and extracellular vesicles from human PBMCs, and implicate the use of secretome fractions as valuable material for the development of cell-free therapies in regenerative medicine.
Journal ArticleDOI
Non-classical monocytes as mediators of tissue destruction in arthritis
Antonia Puchner,Victoria Saferding,Michael Bonelli,Yohei Mikami,Melanie Hofmann,Julia S. Brunner,Michael Caldera,E Goncalves-Alves,Nikolaus B. Binder,Anita Fischer,Elisabeth Simader,Carl W. Steiner,H. Leiss,Silvia Hayer,Birgit Niederreiter,Thomas Karonitsch,Marije I. Koenders,Bruno K. Podesser,John J. O'Shea,Jörg Menche,Josef S Smolen,Kurt Redlich,Stephan Blüml +22 more
TL;DR: Non-classical monocytes are pivotal cells in arthritis tissue damage and a possible target for therapeutically intervention for the prevention of inflammatory joint damage.
Journal ArticleDOI
Different pro-angiogenic potential of γ-irradiated PBMC-derived secretome and its subfractions
Tanja Wagner,Denise Traxler,Elisabeth Simader,Lucian Beer,Marie Sophie Narzt,Florian Gruber,Sibylle Madlener,Maria Laggner,Michael Erb,Vera Vorstandlechner,Alfred Gugerell,Christine Radtke,Massimiliano Gnecchi,Massimiliano Gnecchi,Anja Peterbauer,Maria Gschwandtner,Erwin Tschachler,Claudia Keibl,Paul Slezak,Hendrik Jan Ankersmit,Michael Mildner +20 more
TL;DR: The results suggest that secretome-based wound healing represents a promising new therapeutic avenue, and strongly recommend using the complete secretome instead of purified subfractions, such as EVs, to exploit its full regenerative capacity.
Journal ArticleDOI
Safety and tolerability of topically administered autologous, apoptotic PBMC secretome (APOSEC) in dermal wounds: a randomized Phase 1 trial (MARSYAS I).
Elisabeth Simader,Denise Traxler,Mohammad Mahdi Kasiri,Helmut Hofbauer,Michael Wolzt,Christoph Glogner,Angela Storka,Michael Mildner,Ghazaleh Gouya,Alexandra Geusau,Carola Fuchs,Claudia Eder,Alexandra Graf,Michaela Schaden,Bahar Golabi,Marie-Bernadette Aretin,Susanne Suessner,Christian Gabriel,Walter Klepetko,Erwin Tschachler,Hendrik Jan Ankersmit +20 more
TL;DR: Evaluating the safety of two different doses of topically administered autologous APOSEC, the secretome of apoptotic peripheral blood mononuclear cells, in healthy male volunteers with artificial dermal wounds found both low- and high-dose treatments were well tolerated.
Journal ArticleDOI
Dying blood mononuclear cell secretome exerts antimicrobial activity.
Mohammad Mahdi Kasiri,Lucian Beer,Lucas Nemec,Florian Gruber,Sabine Pietkiewicz,Thomas Haider,Elisabeth Simader,Denise Traxler,Thomas Schweiger,Stefan Janik,Shahrokh Taghavi,Christian Gabriel,Michael Mildner,Hendrik Jan Ankersmit +13 more
TL;DR: Several activities are attributed to antimicrobial peptides, including bacterial killing, leucocyte recruitment and angiogenesis, and whether AMPs are present in the MNC secretome of white blood cells that are beneficial in experimental wound healing is not known.