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Elizabeth A. Warner
Researcher at University of Florida
Publications - 8
Citations - 511
Elizabeth A. Warner is an academic researcher from University of Florida. The author has contributed to research in topics: Sepsis & Innate immune system. The author has an hindex of 7, co-authored 8 publications receiving 477 citations.
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Journal ArticleDOI
Clinical Microfluidics for Neutrophil Genomics and Proteomics
Kenneth T. Kotz,Wenzong Xiao,Wenzong Xiao,Carol L. Miller-Graziano,Wei-Jun Qian,Aman Russom,Elizabeth A. Warner,Lyle L. Moldawer,Asit De,Paul E. Bankey,Brianne O. Petritis,David G. Camp,Alan E. Rosenbach,Jeremy Goverman,Shawn P. Fagan,Bernard H. Brownstein,Daniel Irimia,Weihong Xu,Julie Wilhelmy,Michael N. Mindrinos,Richard D. Smith,Ronald W. Davis,Ronald G. Tompkins,Mehmet Toner +23 more
TL;DR: The preliminary results from a small cohort of subjects in this study and healthy controls show a unique time-dependent gene expression pattern clearly demonstrating the ability of this tool to discriminate temporal transcriptional events of neutrophils within a clinical setting.
Journal ArticleDOI
Sepsis Induces Early Alterations in Innate Immunity That Impact Mortality to Secondary Infection
Matthew J. Delano,Terri C. Thayer,Sonia Gabrilovich,Kindra M. Kelly-Scumpia,Robert D. Winfield,Philip O. Scumpia,Alex G. Cuenca,Elizabeth A. Warner,Shannon M. Wallet,Mark A. Wallet,Kerri A. O’Malley,Reuben Ramphal,Michael Clare-Salzer,Philip A. Efron,Clayton E. Mathews,Lyle L. Moldawer +15 more
TL;DR: It is demonstrated that sepsis promotes selective early, impaired innate immune responses, primarily in neutrophils, that lead to a pathogen-specific, increased susceptibility to secondary infections.
Journal ArticleDOI
Neutrophil mobilization from the bone marrow during polymicrobial sepsis is dependent on CXCL12 signaling.
Matthew J. Delano,Kindra M. Kelly-Scumpia,Terri C. Thayer,Robert D. Winfield,Philip O. Scumpia,Alex G. Cuenca,Phillips B. Harrington,Kerri A. O’Malley,Elizabeth A. Warner,Sonia Gabrilovich,Clayton E. Mathews,Drake LaFace,Paul G. Heyworth,Reuben Ramphal,Robert M. Strieter,Lyle L. Moldawer,Philip A. Efron +16 more
TL;DR: It is concluded that changes in the pattern of CXCL12 signaling during sepsis are essential for neutrophil bone marrow mobilization and host survival but have little impact on bone marrow granulopoiesis.
Journal ArticleDOI
Microfluidics-based capture of human neutrophils for expression analysis in blood and bronchoalveolar lavage
Elizabeth A. Warner,Kenneth T. Kotz,Ricardo Ungaro,Amer Abouhamze,M. Cecilia Lopez,Alex G. Cuenca,Kindra M. Kelly-Scumpia,Claudia Roberta de Castro Moreno,Kerri A. O’Malley,Jennifer Lanz,Henry V. Baker,Larry Martin,Mehmet Toner,Ronald G. Tompkins,Philip A. Efron,Lyle L. Moldawer +15 more
TL;DR: A novel microfluidic technique that isolates PMNs by capturing CD66b+ cells and compared it with dextran-Ficoll gradient isolation is used and indicated that LPS stimulation was the primary factor affecting gene expression patterns among all ex vivo samples.
Journal ArticleDOI
Hypothalamic Tuberculoma Associated with Secondary Panhypopituitarism
TL;DR: An unusual case of a hypothalamic tuberculoma is presented in a man, who initially presented with signs and symptoms consistent with panhypopituitarism, and treatment with several antituberculous medications led to clinical improvement and radiographic resolution of the disease.