Weihong Xu

TL;DR: This study shows that, although acute inflammatory stresses from different etiologies result in highly similar genomic responses in humans, the responses in corresponding mouse models correlate poorly with the human conditions and also, one another.

TL;DR: It is shown that critical injury in humans induces a genomic storm with simultaneous changes in expression of innate and adaptive immunity genes that alter the status of these genes in the immune system.

TL;DR: The complete SEQC data sets, comprising >100 billion reads, provide unique resources for evaluating RNA-seq analyses for clinical and regulatory settings, and measurement performance depends on the platform and data analysis pipeline, and variation is large for transcript-level profiling.

TL;DR: Using chemical genetics, it is shown that kinase inhibitors bypass autophosphorylation to activate the RNase by an alternate mode that enforces XBP1 splicing and averts mRNA decay and apoptosis.

TL;DR: The role of long noncoding RNA (lncRNA) in adult heart is unknown; also unclear is how lncRNA modulates nucleosome remodelling as discussed by the authors. But they identify a cluster of LncRNA transcripts from myosin heavy chain 7 (Myh7) loci and demonstrate a new lnc RNA-chromatin mechanism for heart failure.