S
Shawn P. Fagan
Researcher at Harvard University
Publications - 54
Citations - 1469
Shawn P. Fagan is an academic researcher from Harvard University. The author has contributed to research in topics: Burn injury & Population. The author has an hindex of 19, co-authored 54 publications receiving 1290 citations. Previous affiliations of Shawn P. Fagan include Shriners Hospitals for Children & University of Michigan.
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Journal ArticleDOI
Clinical Microfluidics for Neutrophil Genomics and Proteomics
Kenneth T. Kotz,Wenzong Xiao,Wenzong Xiao,Carol L. Miller-Graziano,Wei-Jun Qian,Aman Russom,Elizabeth A. Warner,Lyle L. Moldawer,Asit De,Paul E. Bankey,Brianne O. Petritis,David G. Camp,Alan E. Rosenbach,Jeremy Goverman,Shawn P. Fagan,Bernard H. Brownstein,Daniel Irimia,Weihong Xu,Julie Wilhelmy,Michael N. Mindrinos,Richard D. Smith,Ronald W. Davis,Ronald G. Tompkins,Mehmet Toner +23 more
TL;DR: The preliminary results from a small cohort of subjects in this study and healthy controls show a unique time-dependent gene expression pattern clearly demonstrating the ability of this tool to discriminate temporal transcriptional events of neutrophils within a clinical setting.
Journal ArticleDOI
Burn Injury Reduces Neutrophil Directional Migration Speed in Microfluidic Devices
Kathryn L. Butler,Vijayakrishnan Ambravaneswaran,Nitin Agrawal,M Bilodeau,Mehmet Toner,Ronald G. Tompkins,Shawn P. Fagan,Daniel Irimia +7 more
TL;DR: Comparisons with samples from burn patients revealed impaired directional migration speed starting as early as 24 hours after burn injury, reaching a minimum at 72–120 hours, correlated to the size of the burn injury and potentially serving as an early indicator for concurrent infections.
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Engineered composite tissue as a bioartificial limb graft
Bernhard J. Jank,Linjie Xiong,Philipp T. Moser,Jacques P. Guyette,Xi Ren,Curtis L. Cetrulo,David A. Leonard,Leopoldo Fernandez,Shawn P. Fagan,Harald C. Ott +9 more
TL;DR: An autologous, bio-artificial graft based on native extracellular matrix and patient derived cells could be produced on demand and would not require immunosuppression after transplantation.
Journal ArticleDOI
Stem cells and burns: review and therapeutic implications.
Kathryn L. Butler,Jeremy Goverman,Jeremy Goverman,Harry Ma,Alan J. Fischman,Alan J. Fischman,Yong-Ming Yu,Yong-Ming Yu,M Bilodeau,Ali M. Rad,Ali A. Bonab,Ronald G. Tompkins,Ronald G. Tompkins,Shawn P. Fagan,Shawn P. Fagan +14 more
TL;DR: Through a review of the literature, this article seeks to illustrate applications of stem cell therapy to burn care and to highlight promising areas of research.
Journal ArticleDOI
Benchmarking Outcomes in the Critically Injured Burn Patient
Matthew B. Klein,Jeremy Goverman,Douglas Hayden,Shawn P. Fagan,Grace P. McDonald-Smith,Andrew K. Alexander,Richard L. Gamelli,Nicole S. Gibran,Celeste C. Finnerty,Marc G. Jeschke,Brett D. Arnoldo,Bram Wispelwey,Michael N. Mindrinos,Wenzhong Xiao,Shari Honari,Philip H. Mason,David A. Schoenfeld,David N. Herndon,Ronald G. Tompkins +18 more
TL;DR: This study provides the current benchmark for major burn patients and shows that modern day surgical and medically intensive management has markedly improved to the point where patients younger than 55 years with severe burn injuries and inhalation injury can expect to survive these devastating conditions.