E
Elizabeth Blackwood
Researcher at Genentech
Publications - 51
Citations - 6551
Elizabeth Blackwood is an academic researcher from Genentech. The author has contributed to research in topics: Kinase & Cancer. The author has an hindex of 29, co-authored 51 publications receiving 6119 citations. Previous affiliations of Elizabeth Blackwood include Pfizer & Fred Hutchinson Cancer Research Center.
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Journal ArticleDOI
P21-activated kinase 1 (PAK1) as a therapeutic target in BRAF wild-type melanoma.
Christy C. Ong,Adrian M. Jubb,Diana Jakubiak,Wei Zhou,Joachim Rudolph,Peter M. Haverty,Marcin Kowanetz,Yibing Yan,Jarrod Tremayne,Richard Lisle,Adrian L. Harris,Lori Friedman,Marcia Belvin,Mark R. Middleton,Elizabeth Blackwood,Hartmut Koeppen,Klaus P. Hoeflich +16 more
TL;DR: Evidence is provided for a functional role of PAK1 in BRAF wild-type melanoma and therapeutic use ofPAK inhibitors in this indication.
Journal ArticleDOI
Phosphoproteomic Analysis Implicates the mTORC2-FoxO1 Axis in VEGF Signaling and Feedback Activation of Receptor Tyrosine Kinases
Guanglei Zhuang,Kebing Yu,Zhaoshi Jiang,Alicia S. Chung,Jenny Yao,Connie Ha,Karen Toy,Robert Soriano,Benjamin Haley,Elizabeth Blackwood,Deepak Sampath,Carlos Bais,Jennie R. Lill,Napoleone Ferrara +13 more
TL;DR: This study provides a global and dynamic view of VEGF-regulated phosphorylation events and implicates the mTORC2-FoxO1 axis in V EGF receptor signaling and reprogramming of receptor tyrosine kinases in human endothelial cells.
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Design of Selective PAK1 Inhibitor G-5555: Improving Properties by Employing an Unorthodox Low-pK a Polar Moiety.
Chudi Ndubaku,James J. Crawford,Joy Drobnick,Ignacio Aliagas,David A. Campbell,Ping Dong,Laura M. Dornan,Sergio G. Durón,Jennifer Epler,Lewis J. Gazzard,Christopher E. Heise,Klaus P. Hoeflich,Diana Jakubiak,Hank La,Wendy Lee,Baiwei Lin,Joseph P. Lyssikatos,Jasna Maksimoska,Ronen Marmorstein,Lesley J. Murray,Thomas O'Brien,Angela Oh,Sreemathy Ramaswamy,Weiru Wang,Xianrui Zhao,Yu Zhong,Elizabeth Blackwood,Joachim Rudolph +27 more
TL;DR: Mouse xenograft PK/PD studies concluded that dose-dependent pathway modulation was achievable and paves the way for further in vivo investigations of PAK1 function in cancer and other diseases.
Journal ArticleDOI
Identification of Preferred Chemotherapeutics for Combining with a CHK1 Inhibitor
Yang Xiao,Judi Ramiscal,Kaska Kowanetz,Christopher Del Nagro,Shiva Malek,Marie Evangelista,Elizabeth Blackwood,Peter K. Jackson,Thomas O'Brien +8 more
TL;DR: GNE-783, a novel checkpoint kinase-1 (CHK1) inhibitor, enhances the activity of gemcitabine by disabling the S- and G2 cell-cycle checkpoints following DNA damage, indicating a preference for enhanced chemopotentiation of select agents within tumor types.