Karen Toy

TL;DR: The RANTES protein3 of the C-C class causes the selective migration of human blood monocytes and of T lymphocytes expressing the cell surface antigens CD4 and UCHL1, and may provide insight into the workings of T cell memory.

TL;DR: Recurrent gene fusions and splice alterations to be frequent mechanisms for inactivation of NF2, BAP1 and SETD2 are found and alterations in Hippo, mTOR, histone methylation, RNA helicase and p53 signaling pathways in MPMs are identified.

TL;DR: Gene expression analysis identified a five-gene set that enabled the molecular classification of chRCC, renal oncocytoma and pRCC and observed upregulation of the anti-apoptotic factor BIRC7 in MiTF-high RCC tumors, suggesting a potential therapeutic role for BIRC 7 inhibitors.

TL;DR: The data suggest that tumors with acquired MEK inhibitor resistance remain dependent on the MAPK pathway and are therefore sensitive to inhibitors that act downstream of the mutated MEK target, and provide a rationale for cotargeting multiple nodes within theMAPK signaling cascade in K-ras mutant tumors to maximize therapeutic benefit for patients.

TL;DR: Key findings are the expression gradient in the healthy adult colon and the involvement of novel gene families, as well as established candidate genes in the pathogenesis of ulcerative colitis.