E
Elizabeth Crowne
Researcher at University Hospitals Bristol NHS Foundation Trust
Publications - 79
Citations - 2320
Elizabeth Crowne is an academic researcher from University Hospitals Bristol NHS Foundation Trust. The author has contributed to research in topics: Diabetes mellitus & Adrenal insufficiency. The author has an hindex of 25, co-authored 70 publications receiving 2092 citations. Previous affiliations of Elizabeth Crowne include Bristol Royal Hospital for Children & Health and Safety Executive.
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Journal ArticleDOI
Type 2 diabetes in obese white children
TL;DR: These are the first reported obese, white cases from the UK to present with type 2 diabetes mellitus associated with significant obesity, and it is believed this clinical scenario will become more prevalent given the epidemic of childhood obesity in this country.
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Physical activity patterns in nonobese and obese children assessed using minute-by-minute accelerometry.
Angie S Page,Ashley R Cooper,Emmanuel Stamatakis,LJ Foster,Elizabeth Crowne,Matthew A. Sabin,Julian P.H. Shield +6 more
TL;DR: Hourly patterns of activity indicated a tendency in obese children to be less active than nonobese children at times when activity was more likely to be determined by free choice, particularly outside of school time.
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KSR2 Mutations Are Associated with Obesity, Insulin Resistance, and Impaired Cellular Fuel Oxidation
Laura R. Pearce,Neli Atanassova,Matthew C. Banton,Bill Bottomley,Agatha A. van der Klaauw,Jean-Pierre Revelli,Audrey E. Hendricks,Julia M. Keogh,Elana Henning,Deon Doree,Sabrina Jeter-Jones,Sumedha Garg,Elena G. Bochukova,Rebecca Bounds,Sofie Ashford,Emma L Gayton,Peter C. Hindmarsh,Julian P.H. Shield,Elizabeth Crowne,David Barford,Nicholas J. Wareham,Stephen O'Rahilly,Michael P. Murphy,David R. Powell,Inês Barroso,Inês Barroso,I. Sadaf Farooqi +26 more
TL;DR: KSR2 is established as an important regulator of energy intake, energy expenditure, and substrate utilization in humans and modulation of KSR2-mediated effects may represent a novel therapeutic strategy for obesity and type 2 diabetes.
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Symptomatic adrenal insufficiency presenting with hypoglycaemia in children with asthma receiving high dose inhaled fluticasone propionate.
TL;DR: For example, children taking high dose fluticasone propionate may present with hypoglycaemia secondary to iatrogenic adrenal suppression as mentioned in this paper, which may indicate that they are at risk of developing diabetes.
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Novel mutations of the growth hormone 1 (GH1) gene disclosed by modulation of the clinical selection criteria for individuals with short stature
David Stuart Millar,M. D. Lewis,Martin Horan,Victoria Elizabeth Newsway,T Easter,John Gregory,Linda Fryklund,Martin Norin,Elizabeth Crowne,Sally J. Davies,Phillip Edwards,Jeremy Kirk,Kim Waldron,Patricia J. Smith,John A. Phillips,Maurice F. Scanlon,Michael Krawczak,David Neil Cooper,Annie M. Procter +18 more
TL;DR: Subtle mutations in the growth hormone 1 (GH1) gene are more prevalent than previously recognized and although most may be insufficient on their own to account for the observed clinical phenotype, they are nevertheless likely to play a contributory role in the etiology of short stature.