M
Martin Horan
Researcher at University of New South Wales
Publications - 29
Citations - 1027
Martin Horan is an academic researcher from University of New South Wales. The author has contributed to research in topics: Growth hormone receptor & Gene. The author has an hindex of 16, co-authored 29 publications receiving 949 citations. Previous affiliations of Martin Horan include Cardiff University & University of Wales.
Papers
More filters
Journal ArticleDOI
Essential Requirement for PP2A Inhibition by the Oncogenic Receptor c-KIT Suggests PP2A Reactivation as a Strategy to Treat c-KIT+ Cancers
Kathryn G. Roberts,Amanda Smith,Fiona McDougall,Helen Carpenter,Martin Horan,Paolo Neviani,Jason A. Powell,Daniel Thomas,Mark A. Guthridge,Danilo Perrotti,Alistair T. R. Sim,Leonie K. Ashman,Nicole M. Verrills +12 more
TL;DR: It is shown thatPP2A inhibition is essential for c-KIT-mediated tumorigenesis, and that reactivating PP2A may offer an attractive strategy to treat drug-resistant c- KIT(+) cancers.
Journal ArticleDOI
Review: Quantifying Mitochondrial Dysfunction in Complex Diseases of Aging
TL;DR: Two methodologies that have been developed for measuring mitochondrial function are described and compared and it is concluded that the methodologies are complementary, and researchers may need to examine multiple biological systems to unravel complex diseases of aging.
Journal ArticleDOI
Human growth hormone 1 (GH1) gene expression: complex haplotype-dependent influence of polymorphic variation in the proximal promoter and locus control region.
Martin Horan,David Stuart Millar,Jürgen Hedderich,Geraint F. Lewis,Vicky Newsway,Neil Mo,Linda Fryklund,Annie M. Procter,Michael Krawczak,David Neil Cooper +9 more
TL;DR: The prediction and functional testing of hitherto unobserved super‐maximal and sub‐minimal promoter haplotypes was used to test the efficacy of the haplotype partitioning approach and identified six SNPs as major determinants of GH1 gene expression.
Journal ArticleDOI
Novel mutations of the growth hormone 1 (GH1) gene disclosed by modulation of the clinical selection criteria for individuals with short stature
David Stuart Millar,M. D. Lewis,Martin Horan,Victoria Elizabeth Newsway,T Easter,John Gregory,Linda Fryklund,Martin Norin,Elizabeth Crowne,Sally J. Davies,Phillip Edwards,Jeremy Kirk,Kim Waldron,Patricia J. Smith,John A. Phillips,Maurice F. Scanlon,Michael Krawczak,David Neil Cooper,Annie M. Procter +18 more
TL;DR: Subtle mutations in the growth hormone 1 (GH1) gene are more prevalent than previously recognized and although most may be insufficient on their own to account for the observed clinical phenotype, they are nevertheless likely to play a contributory role in the etiology of short stature.
Journal ArticleDOI
Characterization of the somatic mutational spectrum of the neurofibromatosis type 1 (NF1) gene in neurofibromatosis patients with benign and malignant tumors.
Meena Upadhyaya,Song Han,Claudia Consoli,Elisa Majounie,Martin Horan,Nicholas Stuart Tudor Thomas,Christopher Potts,Sian Wyn Griffiths,Martino Ruggieri,Andreas von Deimling,David Neil Cooper +10 more
TL;DR: Findings are consistent with the view that NF1 tumorigenesis is a complex multistep process involving a variety of different types of genetic defect at multiple loci.