E
Elizabeth H. Blackburn
Researcher at University of California, San Francisco
Publications - 347
Citations - 54331
Elizabeth H. Blackburn is an academic researcher from University of California, San Francisco. The author has contributed to research in topics: Telomere & Telomerase. The author has an hindex of 108, co-authored 344 publications receiving 50726 citations. Previous affiliations of Elizabeth H. Blackburn include Cornell University & Blackburn College.
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Identification of a specific telomere terminal transferase activity in tetrahymena extracts
TL;DR: It is proposed that the novel telomere terminal transferase is involved in the addition of telomeric repeats necessary for the replication of chromosome ends in eukaryotes.
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Structure and function of telomeres
TL;DR: The DNA of telomeres—the terminal DNA-protein complexes of chromosomes—differs notably from other DNA sequences in both structure and function, and has been shown to be essential for telomere maintenance and long-term viability.
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Accelerated telomere shortening in response to life stress
Elissa S. Epel,Elizabeth H. Blackburn,Jue Lin,Firdaus S. Dhabhar,Nancy E. Adler,Jason D. Morrow,Richard M. Cawthon +6 more
TL;DR: Evidence is provided that psychological stress--both perceived stress and chronicity of stress--is significantly associated with higher oxidative stress, lower telomerase activity, and shorter telomere length, in peripheral blood mononuclear cells from healthy premenopausal women.
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Switching and Signaling at the Telomere
TL;DR: The structure of telomeres, the protective DNA-protein complexes at eukaryotic chromosomal ends, and several molecular mechanisms involved in telomere functions are described.
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Dynamic Imaging of Genomic Loci in Living Human Cells by an Optimized CRISPR/Cas System
Baohui Chen,Luke A. Gilbert,Beth A. Cimini,Joerg Schnitzbauer,Wei Zhang,Gene-Wei Li,Jason Park,Elizabeth H. Blackburn,Jonathan S. Weissman,Lei S. Qi,Bo Huang +10 more
TL;DR: Using an EGFP-tagged endonuclease-deficient Cas9 protein and a structurally optimized small guide (sg) RNA, robust imaging of repetitive elements in telomeres and coding genes in living cells is demonstrated by repurposing the bacterial CRISPR/Cas system.