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Elizabeth Hahn-Dantona
Researcher at Stony Brook University
Publications - 10
Citations - 1264
Elizabeth Hahn-Dantona is an academic researcher from Stony Brook University. The author has contributed to research in topics: Matrix metalloproteinase & Enzyme activator. The author has an hindex of 8, co-authored 10 publications receiving 1215 citations. Previous affiliations of Elizabeth Hahn-Dantona include Memorial Sloan Kettering Cancer Center & Scripps Research Institute.
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Journal ArticleDOI
Activation of Matrix Metalloproteinase-9 (MMP-9) via a Converging Plasmin/Stromelysin-1 Cascade Enhances Tumor Cell Invasion
Noemi RAMOS-DeSIMONE,Elizabeth Hahn-Dantona,John D. Sipley,Hideaki Nagase,Deborah L. French,James P. Quigley +5 more
TL;DR: The activated MMP-9 enhances the invasive phenotype of the cultured cells as their ability to both degrade extracellular matrix and transverse basement membrane is significantly increased following zymogen activation.
Journal ArticleDOI
The low density lipoprotein receptor-related protein modulates levels of matrix metalloproteinase 9 (MMP-9) by mediating its cellular catabolism.
Elizabeth Hahn-Dantona,Jose F. Ruiz,Paul Bornstein,Dudley K. Strickland,Dudley K. Strickland +4 more
TL;DR: It is demonstrated that LRP is a functional receptor for MMP-9 and suggested a major role for LRP in modulating remodeling of the extracellular matrix by regulatingextracellular proteinase activity.
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The Low Density Lipoprotein Receptor-related Protein LRP Is Regulated by Membrane Type-1 Matrix Metalloproteinase (MT1-MMP) Proteolysis in Malignant Cells
TL;DR: It is demonstrated that the presentation of LRP and the subsequent uptake of its ligands by malignant cells are both strongly regulated by MT1-MMP, a key protease in cell invasion and a physiological activator of MMP-2.
Journal ArticleDOI
Activation of ProMMP‐9 by a Plasmin/MMP‐3 Cascade in a Tumor Cell Model: Regulation by Tissue Inhibitors of Metalloproteinases
Elizabeth Hahn-Dantona,Noemi RAMOS-DeSIMONE,John D. Sipley,Hideaki Nagase,Deborah L. French,James P. Quigley +5 more
TL;DR: The activated MMP‐9 enhances the invasive phenotype of the cultured cells as their ability to transverse basement membrane is significantly increased following zymogen activation, and this enhanced tissue remodeling capability is demonstrated through the use of a specific anti‐M MP‐9‐blocking monoclonal antibody.
Journal ArticleDOI
Proangiogenic role of neutrophil-like inflammatory heterophils during neovascularization induced by growth factors and human tumor cells.
Andries Zijlstra,Marco Seandel,Marco Seandel,Marco Seandel,Tatyana A. Kupriyanova,Tatyana A. Kupriyanova,Tatyana A. Kupriyanova,Juneth J. Partridge,Juneth J. Partridge,Juneth J. Partridge,Mark A. Madsen,Mark A. Madsen,Mark A. Madsen,Elizabeth Hahn-Dantona,Elizabeth Hahn-Dantona,Elizabeth Hahn-Dantona,James P. Quigley,James P. Quigley,James P. Quigley,Elena I. Deryugina,Elena I. Deryugina,Elena I. Deryugina +21 more
TL;DR: It is shown that the onset and extent of angiogenesis induced by purified growth factors or by human HT-1080 fibrosarcoma cells correlated with the initial influx of chMMP-9-positive heterophils, indicating a direct proangiogenic role for neutrophil-like leukocytes.