E
Elizabeth J. Cochran
Researcher at Medical College of Wisconsin
Publications - 107
Citations - 7591
Elizabeth J. Cochran is an academic researcher from Medical College of Wisconsin. The author has contributed to research in topics: Alzheimer's disease & Glioma. The author has an hindex of 42, co-authored 97 publications receiving 7013 citations. Previous affiliations of Elizabeth J. Cochran include Rush University & University of California, Irvine.
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Journal ArticleDOI
Upregulation of choline acetyltransferase activity in hippocampus and frontal cortex of elderly subjects with mild cognitive impairment.
Steven T. DeKosky,Milos D. Ikonomovic,Scot D. Styren,Laurel A. Beckett,Stephen R. Wisniewski,David A. Bennett,Elizabeth J. Cochran,Jeffrey H. Kordower,Elliott J. Mufson +8 more
TL;DR: Cognitive deficits in MCI and early AD are not associated with the loss of ChAT and occur despite regionally specific upregulation, suggesting that the earliest cognitive deficits in AD involve brain changes other than simply cholinergic system loss.
Journal ArticleDOI
Loss and atrophy of layer II entorhinal cortex neurons in elderly people with mild cognitive impairment.
Jeffrey H. Kordower,Yaping Chu,Glenn T. Stebbins,Steven T. DeKosky,Elizabeth J. Cochran,David A. Bennett,Elliott J. Mufson +6 more
TL;DR: Autopsy data indicate that atrophy and loss of layer II entorhinal cortex neurons occur in elderly subjects with mild cognitive impairment prior to the onset of dementia and suggests that these changes are not exacerbated in early Alzheimer's disease.
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Clinicopathological findings following intraventricular glial-derived neurotrophic factor treatment in a patient with Parkinson's disease.
Jeffrey H. Kordower,Stéphane Palfi,Er-Yun Chen,Shuang Y. Ma,Timothy Sendera,Elizabeth J. Cochran,Elliott J. Mufson,R. D. Penn,Christopher G. Goetz,Cynthia D. Comella +9 more
TL;DR: There was no evidence of significant regeneration of nigrostriatal neurons or intraparenchymal diffusion of the intracerebroventricular GDNF to relevant brain regions in a 65-year-old man with Parkinson's disease.
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Relation of cerebral infarctions to dementia and cognitive function in older persons
Julie A. Schneider,Robert S. Wilson,Elizabeth J. Cochran,Julia L. Bienias,Steven E. Arnold,Denis A. Evans,David A. Bennett +6 more
TL;DR: Cerebral infarctions are associated with a twofold increase in odds of dementia, and odds are higher in persons with multiple, large, or clinically evident infarction.
Journal ArticleDOI
Decision rules guiding the clinical diagnosis of Alzheimer's disease in two community-based cohort studies compared to standard practice in a clinic-based cohort study.
David A. Bennett,Julie A. Schneider,Neelum T. Aggarwal,Zoe Arvanitakis,Raj C. Shah,Jeremiah F. Kelly,Jacob H. Fox,Elizabeth J. Cochran,Danielle Arends,Anna D Treinkman,Robert S. Wilson +10 more
TL;DR: P prediction rules to guide the clinical diagnosis of Alzheimer’s disease (AD) in two community-based cohort studies without the use of informant interviews, neuroimaging, blood work or routine case conferencing hold promise for reducing the operational costs of epidemiologic studies of aging and AD.