E
Elliott J. Mufson
Researcher at Rush University Medical Center
Publications - 263
Citations - 33127
Elliott J. Mufson is an academic researcher from Rush University Medical Center. The author has contributed to research in topics: Basal forebrain & Cholinergic. The author has an hindex of 91, co-authored 254 publications receiving 31258 citations. Previous affiliations of Elliott J. Mufson include Beth Israel Deaconess Medical Center & St. Joseph's Hospital and Medical Center.
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Journal ArticleDOI
Cholinergic innervation of cortex by the basal forebrain : cytochemistry and cortical connections of the septal area, diagonal band nuclei, nucleus basalis (substantia innominata), and hypothalamus in the rhesus monkey
TL;DR: The organization of projections from the cholinergic neurons of the basal forebrain to neocortex and associated structures was investigated in the rhesus monkey with the help of horseradish peroxidase transport, acetyl‐cholinesterase histochemistry, and choline acetyltransferase immunohis‐tochemistry.
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A phase 1 clinical trial of nerve growth factor gene therapy for Alzheimer disease
Mark H. Tuszynski,Mark H. Tuszynski,Leon J. Thal,Leon J. Thal,Mary Pay,David P. Salmon,Hoi Sang U,Roy A.E. Bakay,Piyush M. Patel,Armin Blesch,H. Lee Vahlsing,H. Lee Vahlsing,Gilbert Ho,Gang Tong,Steven G. Potkin,James H. Fallon,Lawrence A. Hansen,Elliott J. Mufson,Jeffrey H. Kordower,Christine M. Gall,James M. Conner +20 more
TL;DR: A phase 1 trial of ex vivo NGF gene delivery in eight individuals with mild Alzheimer disease, implanting autologous fibroblasts genetically modified to express human NGF into the forebrain found no long-term adverse effects and brain autopsy from one subject suggested robust growth responses to NGF.
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Insula of the old world monkey. III: Efferent cortical output and comments on function.
TL;DR: A collective consideration of afferents and efferents indicates that the insula has connections with principal sensory areas in the olfactory, gustatory, somesthetic, and auditory AI and AII modalities.
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Hippocampal synaptic loss in early Alzheimer's disease and mild cognitive impairment
TL;DR: This study supports the concept that synapse loss is an early event in the disease process and suggests that MCI may be a transition stage between eAD and NCI with synaptic loss a structural correlate involved in cognitive decline.
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Nanoparticle-Based Detection in Cerebral Spinal Fluid of a Soluble Pathogenic Biomarker for Alzheimer’s Disease*
Dimitra Georganopoulou,Lei Chang,Jwa-Min Nam,C. Shad Thaxton,Elliott J. Mufson,William L. Klein,Chad A. Mirkin +6 more
TL;DR: The recently developed ultrasensitive bio-barcode assay was used to measure the concentration of amyloid-beta-derived diffusible ligands (ADDLs), a potential soluble pathogenic Alzheimer's disease marker, in the cerebrospinal fluid of 30 individuals.