E
Elizabeth Kopp
Researcher at Yale University
Publications - 13
Citations - 10630
Elizabeth Kopp is an academic researcher from Yale University. The author has contributed to research in topics: Signal transduction & Innate immune system. The author has an hindex of 9, co-authored 12 publications receiving 10312 citations.
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Journal ArticleDOI
NF-kappa B and Rel proteins: evolutionarily conserved mediators of immune responses
TL;DR: Recently, significant advances have been made in elucidating the details of the pathways through which signals are transmitted to the NF-kappa B:I kappa B complex in the cytosol and their implications for the study of NF-Kappa B.
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Inhibition of NF-kappa B by sodium salicylate and aspirin
Elizabeth Kopp,Sankar Ghosh +1 more
TL;DR: The anti-inflammatory drugs sodium salicylate and aspirin inhibited the activation of NF-kappa B, which further explains the mechanism of action of these drugs.
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MyD88 Is an Adaptor Protein in the hToll/IL-1 Receptor Family Signaling Pathways
Ruslan Medzhitov,Paula Preston-Hurlburt,Elizabeth Kopp,Andrew Stadlen,Chaoqun Chen,Sankar Ghosh,Charles A. Janeway +6 more
TL;DR: MyD88 is implicate as a general adaptor/regulator molecule for the Toll/IL-1R family of receptors for innate immunity and induces activation of NF-kappaB via the Pelle-like kinase IRAK and the TRAF6 protein, similar to IL- 1R-mediated NF- kappaB activation.
Journal ArticleDOI
The Toll-receptor family and control of innate immunity.
Elizabeth Kopp,Ruslan Medzhitov +1 more
TL;DR: Toll receptors and the associated signaling pathways of nuclear factor kappaB may represent the most ancient host defense system found in mammals, insects and plants.
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Recognition of microbial infection by Toll-like receptors.
Elizabeth Kopp,Ruslan Medzhitov +1 more
TL;DR: Two newly identified signaling molecules, TIRAP and TRIF, interact with a subset of the TLRs, suggesting a signaling specificity that may be relevant to the type of infection.