E
Elizabeth S. Gold
Researcher at Seattle Children's Research Institute
Publications - 27
Citations - 1423
Elizabeth S. Gold is an academic researcher from Seattle Children's Research Institute. The author has contributed to research in topics: Transcription factor & Innate immune system. The author has an hindex of 16, co-authored 27 publications receiving 1185 citations. Previous affiliations of Elizabeth S. Gold include Johns Hopkins Center for Communication Programs & Seattle Biomed.
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Journal ArticleDOI
25-Hydroxycholesterol acts as an amplifier of inflammatory signaling
Elizabeth S. Gold,Alan H. Diercks,Irina Podolsky,Rebecca L. Podyminogin,Peter S. Askovich,Piper M. Treuting,Alan Aderem +6 more
TL;DR: This study demonstrates, for the first time, that in addition to its direct antiviral role, 25HC also regulates transcriptional responses and acts as an amplifier of inflammation via AP-1 and that the resulting alteration in inflammatory response leads to increased tissue damage in mice following infection with influenza.
Journal ArticleDOI
Uncovering a macrophage transcriptional program by integrating evidence from motif scanning and expression dynamics.
Stephen A. Ramsey,Sandy L. Klemm,Daniel E. Zak,Kathleen A. Kennedy,Vesteinn Thorsson,Bin Li,Mark Gilchrist,Elizabeth S. Gold,Carrie D. Johnson,Vladimir Litvak,Garnet Navarro,Jared C. Roach,Carrie M. Rosenberger,Alistair G. Rust,Natalya Yudkovsky,Alan Aderem,Ilya Shmulevich +16 more
TL;DR: A novel regulator (TGIF1) that may have a role in macrophage activation was identified and a novel statistical test was developed to assess the significance of the time-lagged correlation.
Journal ArticleDOI
ATF3 protects against atherosclerosis by suppressing 25-hydroxycholesterol–induced lipid body formation
Elizabeth S. Gold,Stephen A. Ramsey,Mark J. Sartain,Jyrki Selinummi,Irina Podolsky,David J. Rodriguez,Robert L. Moritz,Alan Aderem +7 more
TL;DR: The transcription factor ATF3 inhibits lipid body formation in macrophages during atherosclerosis in part by dampening the expression of cholesterol 25-hydroxylase.
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Bright Field Microscopy as an Alternative to Whole Cell Fluorescence in Automated Analysis of Macrophage Images
Jyrki Selinummi,Jyrki Selinummi,Pekka Ruusuvuori,Pekka Ruusuvuori,Irina Podolsky,Adrian Ozinsky,Elizabeth S. Gold,Olli Yli-Harja,Alan Aderem,Ilya Shmulevich +9 more
TL;DR: It is shown that whole cell area detection results using the projected bright field images match closely to the standard approach where cell areas are localized using fluorescence, and concluded that the high contrast bright field projection image can directly replace one fluorescent channel in whole cell quantification.
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Simvastatin augments lipopolysaccharide-induced proinflammatory responses in macrophages by differential regulation of the c-Fos and c-Jun transcription factors.
TL;DR: It is reported in this work that, unexpectedly, simvastatin enhances LPS-induced IL- 12p40 production by murine macrophages, and that it does so by activating the IL-12p40 promoter.