Mark Gilchrist

TL;DR: Cluster analysis of a comprehensive set of transcriptomic data derived from Toll-like receptor-activated macrophages is used to identify a prominent group of genes that appear to be regulated by activating transcription factor 3 (ATF3), a member of the CREB/ATF family of transcription factors.

TL;DR: A novel regulator (TGIF1) that may have a role in macrophage activation was identified and a novel statistical test was developed to assess the significance of the time-lagged correlation.

TL;DR: It is demonstrated that ATF3 also ameliorates allergen-induced airway inflammation and hyperresponsiveness in a mouse model of human asthma, and attenuates the inflammatory responses associated with allergic airway disease.

TL;DR: It is found that using HAc data significantly improves the performance of motif-based TF binding site prediction, and within regions of high HAc, local minima of the HAc ChIP-Seq signal are particularly strongly correlated with TF binding locations.

TL;DR: It is shown that during differentiation, cAMP agonists can cause a large increase in the mRNA and protein levels of several of the pro-inflammatory CXCL and CCL chemokines, which are known to play an important role in the regulation of immune responses, particularly regarding the pathogenesis of asthma and chronic obstructive pulmonary disorder.