V
Vladimir Litvak
Researcher at University of Massachusetts Medical School
Publications - 19
Citations - 4358
Vladimir Litvak is an academic researcher from University of Massachusetts Medical School. The author has contributed to research in topics: Microglia & Transcription factor. The author has an hindex of 18, co-authored 19 publications receiving 3443 citations. Previous affiliations of Vladimir Litvak include Seattle Biomed & Weizmann Institute of Science.
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Journal ArticleDOI
The TREM2-APOE Pathway Drives the Transcriptional Phenotype of Dysfunctional Microglia in Neurodegenerative Diseases
Susanne Krasemann,Susanne Krasemann,Charlotte Madore,Ron Cialic,Caroline Baufeld,Narghes Calcagno,Rachid El Fatimy,Lien Beckers,Elaine O’Loughlin,Yang Xu,Zain Fanek,David J. Greco,Scott T. Smith,George Tweet,Zachary Humulock,Tobias Zrzavy,Patricia Conde-Sanroman,Mar Gacias,Zhiping Weng,Hao Chen,Emily C. Tjon,Fargol Mazaheri,Kristin Hartmann,Asaf Madi,Jason D. Ulrich,Markus Glatzel,Anna Worthmann,Joerg Heeren,Bogdan Budnik,Cynthia A. Lemere,Tsuneya Ikezu,Frank L. Heppner,Vladimir Litvak,David M. Holtzman,Hans Lassmann,Howard L. Weiner,Jordi Ochando,Christian Haass,Oleg Butovsky +38 more
TL;DR: The TREM2-APOE pathway is identified as a major regulator of microglial functional phenotype in neurodegenerative diseases and serves as a novel target that could aid in the restoration of homeostatic microglia.
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Pan-viral specificity of IFN-induced genes reveals new roles for cGAS in innate immunity
John W. Schoggins,Donna A. MacDuff,Naoko Imanaka,Maria D. Gainey,Bimmi Shrestha,Jennifer L. Eitson,Katrina B. Mar,R. Blake Richardson,Alexander V. Ratushny,Vladimir Litvak,Rea Dabelic,Balaji Manicassamy,John D. Aitchison,Alan Aderem,Richard M. Elliott,Adolfo García-Sastre,Vincent R. Racaniello,Eric J. Snijder,Wayne M. Yokoyama,Michael S. Diamond,Herbert W. Virgin,Charles M. Rice +21 more
TL;DR: Comparative analysis reveals that the screened ISGs target positive-sense single-stranded RNA viruses more effectively than negative-sensesingle-strander RNA viruses.
Journal ArticleDOI
Unexpected role of interferon-γ in regulating neuronal connectivity and social behaviour
Anthony J. Filiano,Yang Xu,Nicholas J. Tustison,Rachel Marsh,Wendy Baker,Igor Smirnov,Christopher C. Overall,Sachin P. Gadani,Stephen D. Turner,Zhiping Weng,Sayeda Najamussahar Peerzade,Hao Chen,Kevin S. Lee,Michael Scott,Mark P. Beenhakker,Vladimir Litvak,Jonathan Kipnis +16 more
TL;DR: It is shown that meningeal immunity is also critical for social behaviour; mice deficient in adaptive immunity exhibit social deficits and hyper-connectivity of fronto-cortical brain regions, and suggests a co-evolutionary link between social behaviour and an anti-pathogen immune response driven by IFN-γ signalling.
Journal ArticleDOI
Function of C/EBPdelta in a regulatory circuit that discriminates between transient and persistent TLR4-induced signals.
Vladimir Litvak,Stephen A. Ramsey,Alistair G. Rust,Daniel E. Zak,Kathleen A. Kennedy,Aaron E. Lampano,Matti Nykter,Ilya Shmulevich,Alan Aderem +8 more
TL;DR: This work mathematically modeled transcriptional regulation of the genes encoding interleukin 6 and C/EBPδ and experimentally confirmed the prediction that the combination of an initiate, an amplifier and an attenuator forms a regulatory circuit that discriminates between transient and persistent Toll-like receptor 4–induced signals.
Journal ArticleDOI
Uncovering a macrophage transcriptional program by integrating evidence from motif scanning and expression dynamics.
Stephen A. Ramsey,Sandy L. Klemm,Daniel E. Zak,Kathleen A. Kennedy,Vesteinn Thorsson,Bin Li,Mark Gilchrist,Elizabeth S. Gold,Carrie D. Johnson,Vladimir Litvak,Garnet Navarro,Jared C. Roach,Carrie M. Rosenberger,Alistair G. Rust,Natalya Yudkovsky,Alan Aderem,Ilya Shmulevich +16 more
TL;DR: A novel regulator (TGIF1) that may have a role in macrophage activation was identified and a novel statistical test was developed to assess the significance of the time-lagged correlation.