E
Elizabeth Skippington
Researcher at Genentech
Publications - 23
Citations - 1673
Elizabeth Skippington is an academic researcher from Genentech. The author has contributed to research in topics: Genetic transfer & Escherichia coli. The author has an hindex of 13, co-authored 21 publications receiving 1245 citations. Previous affiliations of Elizabeth Skippington include Australian Research Council & Indiana University.
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Journal ArticleDOI
Global dissemination of a multidrug resistant Escherichia coli clone
Nicola K. Petty,Nouri L. Ben Zakour,Mitchell Stanton-Cook,Elizabeth Skippington,Makrina Totsika,Brian M. Forde,Minh-Duy Phan,Danilo Gomes Moriel,Kate M. Peters,Mark R. Davies,Mark R. Davies,Benjamin A. Rogers,Gordon Dougan,Jesús Rodríguez-Baño,Álvaro Pascual,Johann D. D. Pitout,Mathew Upton,David L. Paterson,Timothy R. Walsh,Mark A. Schembri,Scott A. Beatson +20 more
TL;DR: This study confirms the global dispersal of a single E. coli ST131 clone and demonstrates the role of MGEs and recombination in the evolution of this important MDR pathogen.
Journal ArticleDOI
Optimized arylomycins are a new class of Gram-negative antibiotics.
Peter A. S. Smith,Michael F. T. Koehler,Hany S. Girgis,Donghong Yan,Yongsheng Chen,Yuan Chen,James J. Crawford,Matthew R. Durk,Robert I. Higuchi,Jing Kang,Jeremy Murray,Prasuna Paraselli,Summer Park,Wilson Phung,John G. Quinn,Tucker C. Roberts,Lionel Rouge,Jacob Schwarz,Elizabeth Skippington,John S. Wai,Min Xu,Zhiyong Yu,Hua Zhang,Man-Wah Tan,Christopher E. Heise +24 more
TL;DR: Chemical optimization of arylomycins results in an inhibitor of bacterial type I signal peptidase that shows activity both against multidrug-resistant clinical isolates of Gram-negative bacteria in vitro and in several in vivo infection models.
Journal ArticleDOI
Miniaturized mitogenome of the parasitic plant Viscum scurruloideum is extremely divergent and dynamic and has lost all nad genes.
TL;DR: The mitochondrial genome of an aerobic parasitic plant, the mistletoe Viscum scurruloideum, is presented, which is miniaturized, shows clear signs of rapid and degenerative evolution, and lacks all genes for complex I of the respiratory electron-transfer chain.
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Lateral genetic transfer and the construction of genetic exchange communities.
TL;DR: This work provides a set-based definition of GECs, and reviews the features of actual genetic exchange communities (GECs), adopting first a knowledge-driven approach based on literature, and then a synoptic data-centric bioinformatic approach.
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Monoclonal antibody targeting the β-barrel assembly machine of Escherichia coli is bactericidal.
Kelly M. Storek,Marcy R. Auerbach,Handuo Shi,Natalie K. Garcia,Dawei Sun,Nicholas N. Nickerson,Rajesh Vij,Zhonghua Lin,Nan Chiang,Kellen Schneider,Aaron T. Wecksler,Elizabeth Skippington,Gerald R. Nakamura,Dhaya Seshasayee,James T. Koerber,Jian Payandeh,Peter A. S. Smith,Steven T. Rutherford +17 more
TL;DR: A monoclonal antibody is characterized that selectively and potently antagonizes BamA, which folds and inserts integral outer membrane β-barrel proteins, by binding to a surface-exposed BamA epitope and, as a result, inhibits bacterial cell growth.