M
Man-Wah Tan
Researcher at Genentech
Publications - 69
Citations - 9859
Man-Wah Tan is an academic researcher from Genentech. The author has contributed to research in topics: Caenorhabditis elegans & Innate immune system. The author has an hindex of 40, co-authored 64 publications receiving 8457 citations. Previous affiliations of Man-Wah Tan include Harvard University & Stanford University.
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Journal ArticleDOI
Killing of Caenorhabditis elegans by Pseudomonas aeruginosa used to model mammalian bacterial pathogenesis
TL;DR: It is shown that a C. elegans pathogenicity model that is genetically tractable from the perspectives of both host and pathogen can be used to model mammalian bacterial pathogenesis.
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Molecular mechanisms of bacterial virulence elucidated using a Pseudomonas aeruginosa-Caenorhabditis elegans pathogenesis model.
TL;DR: It is shown that phenazines and other P. aeruginosa factors required for C. elegans killing are also required for pathogenesis in plants and mice, illustrating that this model tackles the dual challenges of identifying bacterial virulence factors as well as host responses to them.
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A Conserved p38 MAP Kinase Pathway in Caenorhabditis elegans Innate Immunity
Dennis H. Kim,Rhonda L. Feinbaum,Geneviève Alloing,Fred E. Emerson,Danielle A. Garsin,Hideki Inoue,Miho Tanaka-Hino,Naoki Hisamoto,Kunihiro Matsumoto,Man-Wah Tan,Frederick M. Ausubel +10 more
TL;DR: RNA interference assays and biochemical analysis established that a p38 ortholog, pmk-1, functions as the downstream MAP kinase required for pathogen defense, suggesting that this MAP kinases signaling cassette represents an ancient feature of innate immune responses in evolutionarily diverse species.
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Definitions and guidelines for research on antibiotic persistence
Naomi N.Q. Balaban,Sophie Helaine,Kim Lewis,Martin Ackermann,Martin Ackermann,Bree B. Aldridge,Dan I. Andersson,Mark P. Brynildsen,Dirk Bumann,Andrew Camilli,James J. Collins,James J. Collins,James J. Collins,Christoph Dehio,Sarah M. Fortune,Jean-Marc Ghigo,Wolf-Dietrich Hardt,Alexander Harms,Matthias Heinemann,Deborah T. Hung,Urs Jenal,Bruce R. Levin,Jan Michiels,Gisela Storz,Man-Wah Tan,Tanel Tenson,Laurence Van Melderen,Annelies S. Zinkernagel +27 more
TL;DR: Scientists working on the response of bacteria to antibiotics define antibiotic persistence and provide practical guidance on how to study bacterial persister cells, and provide a guide to measuring persistence.
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Novel antibody–antibiotic conjugate eliminates intracellular S. aureus
Sophie M. Lehar,Thomas H. Pillow,Min Xu,Leanna Staben,Kimberly Kajihara,Richard Vandlen,Laura DePalatis,Helga Raab,Wouter L. W. Hazenbos,J. Hiroshi Morisaki,Janice Kim,Summer Park,Martine Darwish,Byoung-Chul Lee,Hilda Hernandez,Kelly M. Loyet,Patrick J. Lupardus,Rina Fong,Donghong Yan,Cecile Chalouni,Elizabeth Luis,Yana Khalfin,Emile Plise,Jonathan Cheong,Joseph P. Lyssikatos,Magnus Strandh,Klaus Koefoed,Peter S. Andersen,John A. Flygare,Man-Wah Tan,Eric J. Brown,Sanjeev Mariathasan +31 more
TL;DR: The antibody–antibiotic conjugate is superior to vancomycin for treatment of bacteraemia and provides direct evidence that intracellular S. aureus represents an important component of invasive infections.