M
Mathew Upton
Researcher at University of Plymouth
Publications - 94
Citations - 4742
Mathew Upton is an academic researcher from University of Plymouth. The author has contributed to research in topics: Escherichia coli & Multilocus sequence typing. The author has an hindex of 34, co-authored 86 publications receiving 4188 citations. Previous affiliations of Mathew Upton include Leeds General Infirmary & University of Bath.
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Journal ArticleDOI
Global dissemination of a multidrug resistant Escherichia coli clone
Nicola K. Petty,Nouri L. Ben Zakour,Mitchell Stanton-Cook,Elizabeth Skippington,Makrina Totsika,Brian M. Forde,Minh-Duy Phan,Danilo Gomes Moriel,Kate M. Peters,Mark R. Davies,Mark R. Davies,Benjamin A. Rogers,Gordon Dougan,Jesús Rodríguez-Baño,Álvaro Pascual,Johann D. D. Pitout,Mathew Upton,David L. Paterson,Timothy R. Walsh,Mark A. Schembri,Scott A. Beatson +20 more
TL;DR: This study confirms the global dispersal of a single E. coli ST131 clone and demonstrates the role of MGEs and recombination in the evolution of this important MDR pathogen.
Journal ArticleDOI
Rapid detection of the O25b-ST131 clone of Escherichia coli encompassing the CTX-M-15-producing strains
Olivier Clermont,Hiran Dhanji,Mathew Upton,Tarek M. Gibreel,Andrew J. Fox,David A. Boyd,Michael R. Mulvey,Patrice Nordmann,Etienne Ruppé,J. L. Sarthou,Thierry Frank,Thierry Frank,Sophie Vimont,Guillaume Arlet,Catherine Branger,Neil Woodford,Erick Denamur +16 more
TL;DR: A PCR-based assay is developed that easily identifies a clone with high likelihood of producing ESBLs, including CTX-M-15, which represents 3% of non-ESBL B2 isolates originating from urinary tract infections in Paris.
Journal ArticleDOI
Insights into a Multidrug Resistant Escherichia coli Pathogen of the Globally Disseminated ST131 Lineage: Genome Analysis and Virulence Mechanisms
Makrina Totsika,Scott A. Beatson,Sohinee Sarkar,Minh-Duy Phan,Nicola K. Petty,Nathan L. Bachmann,Marek Szubert,Hanna E. Sidjabat,David L. Paterson,Mathew Upton,Mark A. Schembri +10 more
TL;DR: It is concluded that E. coli ST131 is a geographically widespread, antibiotic resistant clone that has the capacity to produce numerous virulence factors associated with UTI.
Journal ArticleDOI
Major Uropathogenic Escherichia coli Strain Isolated in the Northwest of England Identified by Multilocus Sequence Typing
Siu Ha Lau,Suganya Reddy,John Cheesbrough,F. J. Bolton,Geraldine A. Willshaw,Tom Cheasty,Andrew J. Fox,Mathew Upton +7 more
TL;DR: MLST has identified an important genetic lineage of E. coli, designated sequence type 131 (ST-131), represented by 52 of these isolates, 51 of which were resistant to extended-spectrum cephalosporins.
Journal ArticleDOI
UK epidemic Escherichia coli strains A–E, with CTX-M-15 β-lactamase, all belong to the international O25:H4-ST131 clone
Siu Ha Lau,Mary E. Kaufmann,David M. Livermore,Neil Woodford,Geraldine A. Willshaw,Tom Cheasty,Katie Stamper,Suganya Reddy,John Cheesbrough,F. J. Bolton,Andrew J. Fox,Mathew Upton +11 more
TL;DR: The future spread of the ST131 clone, and its UK variants, should be monitored closely and the pathogenic mechanisms explaining their success should be investigated.