E
Ellappan Babu
Researcher at Texas Tech University Health Sciences Center
Publications - 22
Citations - 1097
Ellappan Babu is an academic researcher from Texas Tech University Health Sciences Center. The author has contributed to research in topics: Cancer & Amino acid. The author has an hindex of 14, co-authored 22 publications receiving 885 citations. Previous affiliations of Ellappan Babu include Georgia Regents University.
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Journal ArticleDOI
Amino Acid Transporters in Cancer and Their Relevance to “Glutamine Addiction”: Novel Targets for the Design of a New Class of Anticancer Drugs
TL;DR: Four amino acid transporters have been found to be expressed at high levels in cancer and show promise in development of new tumor-imaging probes and in tumor-specific delivery of appropriately designed chemotherapeutic agents.
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SLC6A14 (ATB0,+) Protein, a Highly Concentrative and Broad Specific Amino Acid Transporter, Is a Novel and Effective Drug Target for Treatment of Estrogen Receptor-positive Breast Cancer
Senthil Karunakaran,Sabarish Ramachandran,Veena Coothankandaswamy,Selvakumar Elangovan,Ellappan Babu,Sudharsan Periyasamy-Thandavan,Ashish Gurav,Jaya P. Gnana-Prakasam,Nagendra Singh,Patricia V. Schoenlein,Puttur D. Prasad,Muthusamy Thangaraju,Vadivel Ganapathy +12 more
TL;DR: It is shown that the transporter is up-regulated specifically in estrogen receptor (ER)-positive breast cancer, demonstrable with primary human breast cancer tissues andhuman breast cancer cell lines, and an effective drug target for the treatment of ER- positive breast cancer.
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SLC transporters as a novel class of tumour suppressors: identity, function and molecular mechanisms
Yangzom D. Bhutia,Ellappan Babu,Sabarish Ramachandran,Shengping Yang,Muthusamy Thangaraju,Vadivel Ganapathy +5 more
TL;DR: It is likely that additional SLC transporters will be discovered as tumour suppressors in the future, and the likely mechanism for the tumour-suppressive function of SLC26A3 is related to intracellular pH regulation.
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Deletion of the amino acid transporter Slc6a14 suppresses tumour growth in spontaneous mouse models of breast cancer.
Ellappan Babu,Yangzom D. Bhutia,Sabarish Ramachandran,Jaya P. Gnana-Prakasam,Puttur D. Prasad,Muthusamy Thangaraju,Vadivel Ganapathy +6 more
TL;DR: It is demonstrated that SLC6A14 is critical for the maintenance of amino acids nutrition and optimal mammalian target of rapamycin (mTOR) signalling in ER+ breast cancer and that the transporter is a potential target for development of a novel class of anti-cancer drugs targeting amino acid nutrition in tumour cells.
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The amino acid transporter SLC6A14 in cancer and its potential use in chemotherapy
TL;DR: The amino acid transporter SLC6A14 holds great potential not only as a direct drug target for cancer therapy but also for tumor cell-selective delivery of anticancer drugs.