S
Selvakumar Elangovan
Researcher at KIIT University
Publications - 19
Citations - 940
Selvakumar Elangovan is an academic researcher from KIIT University. The author has contributed to research in topics: Breast cancer & DNA methylation. The author has an hindex of 10, co-authored 17 publications receiving 772 citations. Previous affiliations of Selvakumar Elangovan include Georgia Regents University.
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DNMT1 is essential for mammary and cancer stem cell maintenance and tumorigenesis
Rajneesh Pathania,Sabarish Ramachandran,Selvakumar Elangovan,Ravi Padia,Pengyi Yang,Senthilkumar Cinghu,Rajalakshmi Veeranan-Karmegam,Pachiappan Arjunan,Jaya P. Gnana-Prakasam,Fulzele Sadanand,Lirong Pei,Chang Sheng Chang,Jeong Hyeon Choi,Huidong Shi,Santhakumar Manicassamy,Puttur D. Prasad,Suash Sharma,Vadivel Ganapathy,Raja Jothi,Muthusamy Thangaraju +19 more
TL;DR: An essential role for DNMT1 is uncovered in MaSC and CSC maintenance and theDNMT1-ISL1 axis is identified as a potential therapeutic target for breast cancer treatment.
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SLC6A14 (ATB0,+) Protein, a Highly Concentrative and Broad Specific Amino Acid Transporter, Is a Novel and Effective Drug Target for Treatment of Estrogen Receptor-positive Breast Cancer
Senthil Karunakaran,Sabarish Ramachandran,Veena Coothankandaswamy,Selvakumar Elangovan,Ellappan Babu,Sudharsan Periyasamy-Thandavan,Ashish Gurav,Jaya P. Gnana-Prakasam,Nagendra Singh,Patricia V. Schoenlein,Puttur D. Prasad,Muthusamy Thangaraju,Vadivel Ganapathy +12 more
TL;DR: It is shown that the transporter is up-regulated specifically in estrogen receptor (ER)-positive breast cancer, demonstrable with primary human breast cancer tissues andhuman breast cancer cell lines, and an effective drug target for the treatment of ER- positive breast cancer.
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SIRT1 Is Essential for Oncogenic Signaling by Estrogen/Estrogen Receptor α in Breast Cancer
Selvakumar Elangovan,Sabarish Ramachandran,Narayanan Venkatesan,Sudha Ananth,Jaya P. Gnana-Prakasam,Pamela M. Martin,Darren D. Browning,Patricia V. Schoenlein,Puttur D. Prasad,Vadivel Ganapathy,Muthusamy Thangaraju +10 more
TL;DR: SIRT1 inactivation eliminated estrogen/ERα-induced cell growth and tumor development, triggering apoptosis and indicated that SIRT1 is required for estrogen-induced breast cancer growth.
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The Niacin/Butyrate Receptor GPR109A Suppresses Mammary Tumorigenesis by Inhibiting Cell Survival
Selvakumar Elangovan,Rajneesh Pathania,Sabarish Ramachandran,Sudha Ananth,Ravi Padia,Ling Lan,Nagendra Singh,Pamela M. Martin,Lesleyann Hawthorn,Puttur D. Prasad,Vadivel Ganapathy,Muthusamy Thangaraju +11 more
TL;DR: Findings suggest that GPR109A is a tumor suppressor in mammary gland and that pharmacologic induction of this gene in tumor tissues followed by its activation with agonists could be an effective therapeutic strategy to treat breast cancer.
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GPR109A as an Anti-Inflammatory Receptor in Retinal Pigment Epithelial Cells and Its Relevance to Diabetic Retinopathy
Deeksha Gambhir,Sudha Ananth,Rajalakshmi Veeranan-Karmegam,Selvakumar Elangovan,Shanterian Hester,Eric Jennings,Stefan Offermanns,Julian Nussbaum,Sylvia B. Smith,Muthusamy Thangaraju,Vadivel Ganapathy,Pamela M. Martin +11 more
TL;DR: It is speculated that the increased expression of GPR109A and elevation of its ligand β-HB in diabetes are mechanisms by which the tissue attempts to fight inflammation in this disease.