E
Ellen E. Sheets
Researcher at Brigham and Women's Hospital
Publications - 44
Citations - 2646
Ellen E. Sheets is an academic researcher from Brigham and Women's Hospital. The author has contributed to research in topics: Cervical intraepithelial neoplasia & Adenocarcinoma. The author has an hindex of 25, co-authored 44 publications receiving 2589 citations. Previous affiliations of Ellen E. Sheets include Chulalongkorn University & Chinese PLA General Hospital.
Papers
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Journal ArticleDOI
Ki-67, cyclin E, and p16INK4 are complimentary surrogate biomarkers for human papilloma virus-related cervical neoplasia.
Jeffrey T. Keating,Aida Cviko,Sabine Riethdorf,Lutz Riethdorf,Bradley J. Quade,Deqin Sun,Stefan Duensing,Ellen E. Sheets,Karl Münger,Christopher P. Crum +9 more
TL;DR: Ki-67, cyclin E, and p16 are complementary surrogate biomarkers for HPV-related preinvasive squamous cervical disease and use of these biomarkers in combination for resolving diagnostic problems, with an appreciation of potential background staining, is recommended.
Journal Article
NAD(P)H and collagen as in vivo quantitative fluorescent biomarkers of epithelial precancerous changes.
Irene Georgakoudi,Brian C. Jacobson,Markus G. Müller,Ellen E. Sheets,Kamran Badizadegan,David L. Carr-Locke,Christopher P. Crum,Charles W. Boone,Ramachandra R. Dasari,Jacques Van Dam,Michael S. Feld +10 more
TL;DR: It is demonstrated that NAD(P)H and collagen may be used as quantitative fluorescence biomarkers for in vivo detection of dysplasia in the cervix and the esophagus and for diagnostically significant biochemical changes between normal and dysplastic tissues.
Journal ArticleDOI
Trimodal spectroscopy for the detection and characterization of cervical precancers in vivo.
Irene Georgakoudi,Ellen E. Sheets,Markus G. Müller,Vadim Backman,Christopher P. Crum,Kamran Badizadegan,Ramachandra R. Dasari,Michael S. Feld +7 more
TL;DR: Trimodal spectroscopy has the potential to improve the in vivo detection of precancerous cervical changes and is a superior tool for the detection of cervical squamous intraepithelial lesions than any 1 of the techniques alone.
Journal ArticleDOI
Immunotherapy of human cervical high-grade cervical intraepithelial neoplasia with microparticle-delivered human papillomavirus 16 E7 plasmid DNA
Ellen E. Sheets,Robert G. Urban,Christopher P. Crum,Mary Lynne Hedley,Joseph A. Politch,Michael A. Gold,Laila I. Muderspach,Geoffrey Cole,Peggy A. Crowley-Nowick +8 more
TL;DR: ZYC101 warrants further investigation because of a 33% complete histologic responses, a 73% immunologic response, and no serious adverse events.
Journal ArticleDOI
Expression of the p53 Homologue p63 in Early Cervical Neoplasia
Bradley J. Quade,Annie Yang,Yunmei Wang,Deqin Sun,Jeong-Ja Park,Ellen E. Sheets,Aida Cviko,J.M. Federschneider,Roxana Peters,Frank McKeon,Christopher P. Crum +10 more
TL;DR: The broader range of p63 expression relevant to keratin 14 and bcl-2 indicates that p63 may identify additional subsets of benign and neoplastic epithelial basal cells in the cervical transformation zone and may be useful in studying cell differentiation in the early stages of neoplastics change in this region.