Elliot James Bland

TL;DR: A novel role of lactate is established in control of proinflammatory T cell motility and effector functions, which provides a potential molecular mechanism for T cell entrapment and functional changes in inflammatory sites that drive chronic inflammation and offer targeted therapeutic interventions for the treatment of chronic inflammatory disorders.

TL;DR: Current translational attempts to develop agonists at proresolving targets as a strategy to rectify chronic inflammatory status are discussed and it is reasoned this new approach will lead to the identification of better drugs that will establish a new branch of pharmacology, 'resolution pharmacology'.

TL;DR: Oligosaccharides known to enhance the synthesis of penicillin by Penicillium chrysogenum have been presented to human immune cells and their effect measured and results show that the immune system can recognise subtle differences in oligosACcharides and that these oligosac charides could potentially be used to modulate the immune response.

TL;DR: The DCFH-DA method has been designed to provide a highly sensitive, quantifiable, real-time assessment of ROS production by polymorphonuclear leukocytes (PMNs).

TL;DR: It is believed that the effects of oligosaccharides and polysaccharides on ROS production by mammalian and microbial cells can be correlated predicatively with overproduction.