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Eloy Cuadrado
Researcher at University of Amsterdam
Publications - 29
Citations - 1720
Eloy Cuadrado is an academic researcher from University of Amsterdam. The author has contributed to research in topics: Stroke & FOXP3. The author has an hindex of 19, co-authored 28 publications receiving 1453 citations. Previous affiliations of Eloy Cuadrado include Royal Netherlands Academy of Arts and Sciences & Netherlands Institute for Neuroscience.
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Journal ArticleDOI
MMP-9–Positive Neutrophil Infiltration Is Associated to Blood–Brain Barrier Breakdown and Basal Lamina Type IV Collagen Degradation During Hemorrhagic Transformation After Human Ischemic Stroke
Anna Rosell,Eloy Cuadrado,Arantxa Ortega-Aznar,Mar Hernández-Guillamon,Eng H. Lo,Joan Montaner +5 more
TL;DR: A strong neutrophil infiltration in the infarcted and hemorrhagic areas with local high MMP-9 content closely related to basal lamina collagen IV degradation and blood–brain barrier breakdown is shown.
Journal ArticleDOI
Tissue plasminogen activator (t-PA) promotes neutrophil degranulation and MMP-9 release.
Eloy Cuadrado,Laura Ortega,Mar Hernández-Guillamon,Anna Penalba,Israel Fernandez-Cadenas,Anna Rosell,Anna Rosell,Joan Montaner +7 more
TL;DR: The data suggest that neutrophils are good candidates to be the main source of MMP‐9 following t‐PA stroke treatment and in consequence, partially responsible for thrombolysis‐related brain bleedings.
Journal ArticleDOI
Increased intranuclear matrix metalloproteinase activity in neurons interferes with oxidative DNA repair in focal cerebral ischemia.
Yi Yang,Eduardo Candelario-Jalil,Jeffrey Thompson,Eloy Cuadrado,Eduardo Y. Estrada,Anna Rosell,Joan Montaner,Gary A. Rosenberg +7 more
TL;DR: In this paper, increased matrix metalloproteinase (MMP) activity in ischemic brain neurons at early reperfusion was observed, suggesting a possible role in nuclear matrix proteolysis.
Journal ArticleDOI
Vascular MMP-9/TIMP-2 and neuronal MMP-10 up-regulation in human brain after stroke: a combined laser microdissection and protein array study
Eloy Cuadrado,Anna Rosell,Anna Penalba,Mark Slevin,José Alvarez-Sabín,Arantxa Ortega-Aznar,Joan Montaner +6 more
TL;DR: These findings demonstrate a selective cell-dependent MMP secretion, opening the possibility of selectively targeting specific MMPs for neuroprotection or vasculoprotection following stroke.
Journal ArticleDOI
The TNF Receptor Superfamily-NF-κB Axis Is Critical to Maintain Effector Regulatory T Cells in Lymphoid and Non-lymphoid Tissues
Ajithkumar Vasanthakumar,Ajithkumar Vasanthakumar,Yang Liao,Peggy P Teh,Maria Fernanda Pascutti,Anna E. Oja,Alexandra L. Garnham,Alexandra L. Garnham,Renee Gloury,Renee Gloury,Jessica C Tempany,Tom Sidwell,Tom Sidwell,Eloy Cuadrado,Paul Tuijnenburg,Taco W. Kuijpers,Najoua Lalaoui,Lisa A. Mielke,Lisa A. Mielke,Vanessa L. Bryant,Vanessa L. Bryant,Philip D. Hodgkin,Philip D. Hodgkin,John Silke,John Silke,Gordon K. Smyth,Martijn A. Nolte,Wei Shi,Axel Kallies,Axel Kallies +29 more
TL;DR: It is shown that tumor necrosis factor receptor superfamily (TNFRSF) signaling plays a crucial role in the development and maintenance of eTreg cells and mutations in the RelA binding partner NF-κB1 compromised eT Reg cells in humans, suggesting that the TNFRSf-NF-κb axis was required in a non-redundant manner to maintain eTReg cells in mice and humans.