L
Lisa A. Mielke
Researcher at La Trobe University
Publications - 52
Citations - 5432
Lisa A. Mielke is an academic researcher from La Trobe University. The author has contributed to research in topics: Innate lymphoid cell & Cellular differentiation. The author has an hindex of 30, co-authored 47 publications receiving 4626 citations. Previous affiliations of Lisa A. Mielke include Walter and Eliza Hall Institute of Medical Research & Trinity College, Dublin.
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Journal ArticleDOI
Activation of the NLRP3 inflammasome by islet amyloid polypeptide provides a mechanism for enhanced IL-1β in type 2 diabetes
Seth L. Masters,Aisling Dunne,Shoba L. Subramanian,Rebecca L. Hull,Gillian M. Tannahill,Fiona A. Sharp,Christine Becker,Luigi Franchi,Eiji Yoshihara,Zhe Chen,Niamh Mullooly,Lisa A. Mielke,James Harris,Rebecca C. Coll,Kingston H. G. Mills,K. Hun Mok,Philip Newsholme,Gabriel Núñez,Junji Yodoi,Steven E. Kahn,Ed C. Lavelle,Luke A. J. O'Neill +21 more
TL;DR: It is shown that oligomers of islet amyloid polypeptide (IAPP), a protein that formsAmyloid deposits in the pancreas during type 2 diabetes, triggered the NLRP3 inflammasome and generated mature IL-1β.
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The transcriptional regulators IRF4, BATF and IL-33 orchestrate development and maintenance of adipose tissue-resident regulatory T cells
Ajithkumar Vasanthakumar,Kazuyo Moro,Annie Xin,Yang Liao,Renee Gloury,Shimpei Kawamoto,Sidonia Fagarasan,Lisa A. Mielke,Shoukat Afshar-Sterle,Seth L. Masters,Susumu Nakae,Hirohisa Saito,John M. Wentworth,Peng-Peng Li,Wei Liao,Warren J. Leonard,Gordon K. Smyth,Wei Shi,Stephen L. Nutt,Shigeo Koyasu,Axel Kallies +20 more
TL;DR: It is shown that interleukin 33 (IL-33) signaling through the IL-33 receptor ST2 and myeloid differentiation factor MyD88 is essential for development and maintenance of VAT-Treg cells and sustains their transcriptional signature.
Journal ArticleDOI
T-box Transcription Factors Combine with the Cytokines TGF-β and IL-15 to Control Tissue-Resident Memory T Cell Fate
Laura K. Mackay,Erica Wynne-Jones,David Freestone,Daniel G. Pellicci,Daniel G. Pellicci,Lisa A. Mielke,Dane M. Newman,Asolina Braun,Frederick Masson,Frederick Masson,Axel Kallies,Gabrielle T. Belz,Francis R. Carbone +12 more
TL;DR: It is demonstrated that the T-box transcription factors Eomes and T-bet combined to control CD8(+)CD103(+) Trm cell formation, such that their coordinate downregulation was crucial for TGF-β cytokine signaling.
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The transcription factor T-bet is essential for the development of NKp46+ innate lymphocytes via the Notch pathway
Lucille C. Rankin,Lucille C. Rankin,Joanna R Groom,Joanna R Groom,Michael Chopin,Michael Chopin,Marco J Herold,Marco J Herold,Jennifer A. Walker,Lisa A. Mielke,Lisa A. Mielke,Andrew N. J. McKenzie,Sebastian Carotta,Sebastian Carotta,Stephen L. Nutt,Stephen L. Nutt,Gabrielle T. Belz,Gabrielle T. Belz +17 more
TL;DR: This work reports that the transcription factor T-bet (encoded by Tbx21) was essential for the development of NKp46+ ILCs but not of LTi cells or nuocytes, and differentiated solely from the CD4− LTi population, not theCD4+ LTipopulation.
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Retinoic acid expression associates with enhanced IL-22 production by γδ T cells and innate lymphoid cells and attenuation of intestinal inflammation
Lisa A. Mielke,Sarah Jones,Mathilde Raverdeau,Rowan Higgs,Anna M. Stefanska,Joanna R Groom,Joanna R Groom,Alicja Misiak,Lara S. Dungan,Caroline E. Sutton,Gundula Streubel,Adrian P. Bracken,Kingston H. G. Mills +12 more
TL;DR: Retinoic acid attenuates colitis and is associated with increased IL-22 production from γδ T cells and innate lymphoid cells and enhanced antimicrobial peptide expression.