Mark Slevin

TL;DR: The role of o-HA in modulation of angiogenesis during tissue injury, and vascular disease is reviewed, focusing on receptor-mediated signal transduction pathways that have been evaluated.

TL;DR: It is shown that o-HA-induced bovine aortic endothelial cell proliferation, wound recovery, and ERK1/2 activation were also partially dependent on Ras activation, and that o.HA-stimulated tyrosine phosphorylation of the adapter protein Shc, as well as its association with Sos1, suggested a possible role for Src in activation of PLCγ1 and interaction between two distinct o- HA-induced signaling pathways.

TL;DR: VEGF may play an important role in the pathophysiology of acute ischemic stroke and could be of value in future treatment strategies and correlation between stroke severity and VEGF concentration suggests it could be involved in the subsequent repair processes resulting in partial recovery after stroke.

TL;DR: In this large patient-level meta-analysis, models using four or five predictors had acceptable to good discrimination and could inform the location and frequency of observations on patients in clinical practice, explain treatment effects in prior randomised trials, and guide the design of future trials.

TL;DR: Phosphorylation of the CD44 receptor results in an increase in tyrosine phosphorylation, leading to the activation of a cytoplasmic cascade and cell proliferation; this concurs with previous work, which showed that o-HA-induced proliferation of endothelial cells is CD44-receptor-mediated and accompanied by early response gene activation.