Els C. M. Brinkman-Van der Linden

TL;DR: A novel strategy for site-directed PEGylation using glycosyltransferases to attach PEG to O-glycans is presented, which was applied to three therapeutic polypeptides, granulocyte colony stimulating factor (G-CSF), interferon-alpha2b (IFN- alpha2b), and granulocytes/macrophage colony stimulation factor (GM- CSF), which are currently in clinical use.

TL;DR: The identification of OB-BP1/Siglec-6 as a Siglec family member, coupled with its restricted expression pattern, suggests that it may mediate cell-cell recognition events by interacting with sialylated glycoprotein ligands expressed on specific cell populations.

TL;DR: The I- type lectins are a subset of the immunoglobulin superfamily that are capable of carbohydrate-protein interactions and there are I-type lectins recognizing sialic acids, other sugars and glycosaminoglycans.

TL;DR: Since the last common ancestor with apes, humans underwent a concerted bidirectional switch in α2–6-linked Sia expression between airway epithelial cell surfaces and secreted mucins, showing that Sia linkage expression patterns can be conserved during millions of years of evolution within some vertebrate taxa while undergoing sudden major changes in other closely related ones.

TL;DR: The human loss of Neu5Gc may alter biological processes involving siglec-1, and possibly, sigleC-4a or -5, the myelin-associated glycoprotein, which may have some preference for Neu 5Gc.