Elyse Katz

TL;DR: This work proposes a widely applicable statistical methodology for creating a disease progression score (DPS), using multiple biomarkers, for subjects with a neurodegenerative disease, and found the Rey Auditory Verbal Learning Test delayed recall was found to be the earliest biomarker to become abnormal.

TL;DR: A genome-wide association study in an independent set of 1034 cases and 1186 controls using the Illumina genotyping platforms, which replicated the original associations in both PICALM and CR1 and revealed two significant variants close to the APOE locus in limited linkage disequilibrium.

TL;DR: A mathematical model was developed to describe the longitudinal response in Alzheimer's Disease Assessment Scale‐cognitive (ADAS‐cog) obtained from the Alzheimer's disease Neuroimaging Initiative.

TL;DR: This study focuses on AD and shows that the proposed HMM model, when evaluated on the cross validation data, can identify more granular disease stages than the three currently accepted clinical stages of “Normal”, “MCI” (Mild Cognitive Impairment), and “AD”.

TL;DR: A genome-wide association study using clinical decline as measured by changes in the Clinical Dementia Rating-sum of boxes as a quantitative trait to test for single-nucleotide polymorphisms (SNPs) that were associated with the rate of progression in 822 Caucasian subjects of amnestic mild cognitive impairment (MCI).