E
Emanuela Teveroni
Researcher at National Research Council
Publications - 11
Citations - 182
Emanuela Teveroni is an academic researcher from National Research Council. The author has contributed to research in topics: Seminoma & DUX4. The author has an hindex of 6, co-authored 9 publications receiving 133 citations. Previous affiliations of Emanuela Teveroni include The Catholic University of America & Catholic University of the Sacred Heart.
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Journal ArticleDOI
Allele-specific DNA hypomethylation characterises FSHD1 and FSHD2
Patrizia Calandra,Isabella Cascino,Richard J.L.F. Lemmers,Giuliana Galluzzi,Emanuela Teveroni,Emanuela Teveroni,Mauro Monforte,Giorgio Tasca,Enzo Ricci,Fabiola Moretti,Silvère M. van der Maarel,Giancarlo Deidda +11 more
TL;DR: DNA methylation levels of the CpGs distal to the D4Z4 array as a critical region reflecting multiple factors affecting the epigenetics of FSHD are investigated, showing a relationship between PAS-specific methylation and severity of the disease.
Journal ArticleDOI
Estrogens enhance myoblast differentiation in facioscapulohumeral muscular dystrophy by antagonizing DUX4 activity
Emanuela Teveroni,Marsha Pellegrino,Sabrina Sacconi,Sabrina Sacconi,Patrizia Calandra,Isabella Cascino,Stefano Farioli-Vecchioli,Angela Puma,Matteo Garibaldi,Matteo Garibaldi,Roberta Morosetti,Giorgio Tasca,Enzo Ricci,Carlo P. Trevisan,Giuliana Galluzzi,Alfredo Pontecorvi,Marco Crescenzi,Giancarlo Deidda,Fabiola Moretti +18 more
TL;DR: It is demonstrated that estrogens counteract the differentiation impairment of FSHD myoblasts without affecting cell proliferation or survival, and is identified as a potential disease modifier that underlie sex-related differences in FSHd by protecting against myoblast differentiation impairments in this disease.
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Targeting the MDM2/MDM4 Interaction Interface as a Promising Approach for p53 Reactivation Therapy
Marsha Pellegrino,Francesca Mancini,Rossella Lucà,Alice Coletti,Nicola Giacchè,Isabella Manni,Ivan Arisi,Fulvio Florenzano,Emanuela Teveroni,Marianna Buttarelli,Laura Fici,Rossella Brandi,Tiziana Bruno,Maurizio Fanciulli,Mara D'Onofrio,Giulia Piaggio,Roberto Pellicciari,Alfredo Pontecorvi,Jean-Christophe Marine,Antonio Macchiarulo,Fabiola Moretti +20 more
TL;DR: The MDM2/MDM4 interaction interface is identified as a valuable molecular target for therapeutic reactivation of p53 oncosuppressive function by identifying a peptide that mimics the MDM 4 C-terminus, competes with endogenous MDM4 for MDM 2 binding, and activates p53 function.
Journal ArticleDOI
Peptides and peptidomimetics in the p53/MDM2/MDM4 circuitry - a patent review
Emanuela Teveroni,Rossella Lucà,Marsha Pellegrino,Germana Ciolli,Alfredo Pontecorvi,Fabiola Moretti +5 more
TL;DR: A number of promising peptides for p53 reactivation in cancer therapy appear to possess improved features compared to SMC, especially for their ability to simultaneously target the MDM2/MDM4 inhibitors, and their increased specificity.
Journal ArticleDOI
MDM4 actively restrains cytoplasmic mTORC1 by sensing nutrient availability.
Francesca Mancini,Francesca Mancini,Emanuela Teveroni,Giusy Di Conza,Valentina Monteleone,Ivan Arisi,Marsha Pellegrino,Marianna Buttarelli,Luisa Pieroni,Mara D'Onofrio,Andrea Urbani,Alfredo Pontecorvi,Massimiliano Mazzone,Fabiola Moretti +13 more
TL;DR: Data identify MDM4 as a nutrient-sensor able to inhibit mTORC1 and highlight its metabolism-related tumor-suppressing function.