Nicola Giacchè

TL;DR: Genetic or pharmacological inhibition of α-amino-β-carboxymuconate-ε-semialdehyde decarboxylase increases NAD+ and improves mitochondrial function in nematodes and mice, and may have therapeutic potential in kidney and liver disease.

TL;DR: A series of Sirt2 inhibitors based on the 1,2,4-oxadiazole scaffold are reported, providing novel Sirt 2 inhibitors with a compact scaffold and structural insights for further inhibitor improvement.

TL;DR: An integrated computational, chemical, and biological approach is presented that has been instrumental to determine the binding mode of BAs to TGR5, and key residues have been identified that are involved in mediating the binding of B as to the receptor.

TL;DR: The MDM2/MDM4 interaction interface is identified as a valuable molecular target for therapeutic reactivation of p53 oncosuppressive function by identifying a peptide that mimics the MDM 4 C-terminus, competes with endogenous MDM4 for MDM 2 binding, and activates p53 function.

TL;DR: The in vitro antifungal activity was evaluated against different Candida species and low and high capsulated strains of Cryptococcus neoformans and the therapeutic effect was evaluated in terms of animal survival and of fungal growth in the kidneys, the target organ in systemic candidiasis.