M
Marsha Pellegrino
Researcher at National Research Council
Publications - 10
Citations - 268
Marsha Pellegrino is an academic researcher from National Research Council. The author has contributed to research in topics: Downregulation and upregulation & RNA interference. The author has an hindex of 8, co-authored 9 publications receiving 237 citations. Previous affiliations of Marsha Pellegrino include Catholic University of the Sacred Heart.
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Journal ArticleDOI
MDM4 (MDMX) localizes at the mitochondria and facilitates the p53-mediated intrinsic-apoptotic pathway
Francesca Mancini,Francesca Mancini,Giusy Di Conza,Giusy Di Conza,Marsha Pellegrino,Cinzia Rinaldo,Andrea Prodosmo,Simona Giglio,Simona Giglio,Igea D'Agnano,Fulvio Florenzano,Lara Felicioni,Fiamma Buttitta,Antonio Marchetti,Ada Sacchi,Alfredo Pontecorvi,Silvia Soddu,Fabiola Moretti +17 more
TL;DR: It is shown that MDM4 stably localizes at the mitochondria, in which it facilitates mitochondrial localization of p53 phosphorylated at Ser46 (p53Ser46P) and promotes binding between p53Ser 46P and BCL2, release of cytochrome C and apoptosis.
Journal ArticleDOI
Estrogens enhance myoblast differentiation in facioscapulohumeral muscular dystrophy by antagonizing DUX4 activity
Emanuela Teveroni,Marsha Pellegrino,Sabrina Sacconi,Sabrina Sacconi,Patrizia Calandra,Isabella Cascino,Stefano Farioli-Vecchioli,Angela Puma,Matteo Garibaldi,Matteo Garibaldi,Roberta Morosetti,Giorgio Tasca,Enzo Ricci,Carlo P. Trevisan,Giuliana Galluzzi,Alfredo Pontecorvi,Marco Crescenzi,Giancarlo Deidda,Fabiola Moretti +18 more
TL;DR: It is demonstrated that estrogens counteract the differentiation impairment of FSHD myoblasts without affecting cell proliferation or survival, and is identified as a potential disease modifier that underlie sex-related differences in FSHd by protecting against myoblast differentiation impairments in this disease.
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Che-1 modulates the decision between cell cycle arrest and apoptosis by its binding to p53
Agata Desantis,Tommaso Bruno,Valeria Catena,F De Nicola,Frauke Goeman,Simona Iezzi,Cristina Sorino,M P Gentileschi,S. Germoni,Valentina Monteleone,Marsha Pellegrino,M Kann,P D De Meo,Matteo Pallocca,Katja Höpker,Fabiola Moretti,Elisabetta Mattei,Hans Christian Reinhardt,Aristide Floridi,Claudio Passananti,Thomas Benzing,Giovanni Blandino,Maurizio Fanciulli +22 more
TL;DR: Analysis of genome-wide chromatin occupancy by p53 revealed that p53/Che1 interaction results in preferential transactivation of growth arrest p53 target genes over its pro-apoptotic target genes, suggesting Che-1 to be a promising yet attractive drug target for cancer therapy.
Journal ArticleDOI
Targeting the MDM2/MDM4 Interaction Interface as a Promising Approach for p53 Reactivation Therapy
Marsha Pellegrino,Francesca Mancini,Rossella Lucà,Alice Coletti,Nicola Giacchè,Isabella Manni,Ivan Arisi,Fulvio Florenzano,Emanuela Teveroni,Marianna Buttarelli,Laura Fici,Rossella Brandi,Tiziana Bruno,Maurizio Fanciulli,Mara D'Onofrio,Giulia Piaggio,Roberto Pellicciari,Alfredo Pontecorvi,Jean-Christophe Marine,Antonio Macchiarulo,Fabiola Moretti +20 more
TL;DR: The MDM2/MDM4 interaction interface is identified as a valuable molecular target for therapeutic reactivation of p53 oncosuppressive function by identifying a peptide that mimics the MDM 4 C-terminus, competes with endogenous MDM4 for MDM 2 binding, and activates p53 function.
Journal ArticleDOI
IGF-1R/MDM2 Relationship Confers Enhanced Sensitivity to RITA in Ewing Sarcoma Cells
Giusy Di Conza,Marianna Buttarelli,Olimpia Monti,Marsha Pellegrino,Francesca Mancini,Alfredo Pontecorvi,Katia Scotlandi,Fabiola Moretti +7 more
TL;DR: It is shown that the small molecule reactivation of p53 and induction of tumor cell apoptosis (RITA, NSC652287) is highly effective in reducing growth and tumorigenic potential of Ewing sarcoma cell lines, suggesting the presence of additional targets in this tumor histotype.