E
Emelie Salomonsson
Researcher at Swedish Defence Research Agency
Publications - 17
Citations - 521
Emelie Salomonsson is an academic researcher from Swedish Defence Research Agency. The author has contributed to research in topics: Francisella tularensis & Francisella. The author has an hindex of 10, co-authored 16 publications receiving 456 citations. Previous affiliations of Emelie Salomonsson include Umeå University.
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Journal ArticleDOI
Direct repeat-mediated deletion of a type IV pilin gene results in major virulence attenuation of Francisella tularensis
Anna-Lena Forslund,Kerstin Kuoppa,Kerstin Svensson,Emelie Salomonsson,Anders Johansson,Mona Byström,Petra C. F. Oyston,Stephen L. Michell,Richard W. Titball,Richard W. Titball,Laila Noppa,Elisabet Frithz-Lindsten,Mats Forsman,Åke Forsberg +13 more
TL;DR: It is established that repeat‐mediated loss of one of the putative pilin genes in a type B strain results in severe virulence attenuation in mice infected by subcutaneous route and indicates that this putative Pilin is critical for Francisella infections that occur via peripheral routes.
Journal ArticleDOI
Reintroduction of Two Deleted Virulence Loci Restores Full Virulence to the Live Vaccine Strain of Francisella tularensis
Emelie Salomonsson,Emelie Salomonsson,Kerstin Kuoppa,Anna-Lena Forslund,Carl Zingmark,Igor Golovliov,Anders Sjöstedt,Laila Noppa,Åke Forsberg,Åke Forsberg +9 more
TL;DR: It is shown that reintroduction of the two deleted regions restores virulence of LVS in a mouse infection model to a level indistinguishable from that of virulent type B strains.
Journal ArticleDOI
O-Linked Glycosylation of the PilA Pilin Protein of Francisella tularensis: Identification of the Endogenous Protein-Targeting Oligosaccharyltransferase and Characterization of the Native Oligosaccharide
Wolfgang Egge-Jacobsen,Emelie Salomonsson,Finn Erik Aas,Anna-Lena Forslund,Hanne C. Winther-Larsen,Josef Maier,Anna Macellaro,Kerstin Kuoppa,Petra C. F. Oyston,Richard W. Titball,Rebecca M. Thomas,Åke Forsberg,Joann L. Prior,Michael Koomey +13 more
TL;DR: The PglA protein-targeting oligosaccharyltransferase is definitively identified by virtue of its necessity for PilA glycosylation in Francisella tularensis and its sufficiency in Escherichia coli.
Journal ArticleDOI
Efficacy and safety profile of the novel antimicrobial peptide PXL150 in a mouse model of infected burn wounds
Camilla Björn,Camilla Björn,Camilla Björn,Laila Noppa,Emelie Salomonsson,Anna-Lena Johansson,Elin Nilsson,Margit Mahlapuu,Margit Mahlapuu,Joakim Håkansson,Joakim Håkansson +10 more
TL;DR: It is supported that PXL150 has the potential to be an effective and safe drug candidate for the treatment of infected burn wounds and in the non-clinical safety studies, P XL150 showed a favourable safety profile following repeated administration systemically and locally in rats and rabbits.
Journal ArticleDOI
Type IV Pili in Francisella - A Virulence Trait in an Intracellular Pathogen.
TL;DR: Genomic analysis has revealed that Francisella encodes all genes required for expression of functional type IV pili (Tfp), and in this focused review, recent findings regarding this system in the pathogenesis of tularemia are summarized.