P
Petra C. F. Oyston
Researcher at Defence Science and Technology Laboratory
Publications - 130
Citations - 7684
Petra C. F. Oyston is an academic researcher from Defence Science and Technology Laboratory. The author has contributed to research in topics: Francisella tularensis & Yersinia pestis. The author has an hindex of 45, co-authored 127 publications receiving 7155 citations. Previous affiliations of Petra C. F. Oyston include Defence Evaluation and Research Agency & University of Leicester.
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Journal ArticleDOI
Structure and function of the LysR-type transcriptional regulator (LTTR) family proteins.
TL;DR: Structural and transcriptional studies of members of the LTTR family are helping to unravel a compelling paradigm that has evolved from the original observations and conclusions that were made about this family of transcriptional regulators.
Journal ArticleDOI
Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei
Matthew T. G. Holden,Richard W. Titball,Richard W. Titball,Sharon J. Peacock,Sharon J. Peacock,Ana Cerdeño-Tárraga,Timothy P. Atkins,Lisa Crossman,Tyrone Pitt,Carol Churcher,Karen Mungall,Stephen D. Bentley,Mohammed Sebaihia,Nicholas R. Thomson,Nathalie Bason,Ifor R. Beacham,Karen Brooks,Katherine A. Brown,Nat F. Brown,Greg L. Challis,Inna Cherevach,Tracy Chillingworth,Ann Cronin,Ben Crossett,Paul Davis,David DeShazer,Theresa Feltwell,Audrey Fraser,Zahra Hance,Heidi Hauser,S. Holroyd,Kay Jagels,Karen E. Keith,Mark Maddison,Sharon Moule,Claire Price,Michael A. Quail,Ester Rabbinowitsch,Kim Rutherford,Mandy Sanders,Mark Simmonds,Sirirurg Songsivilai,K. Stevens,Sarinna Tumapa,Monkgol Vesaratchavest,Sally Whitehead,Corin Yeats,Bart Barrell,Petra C. F. Oyston,Julian Parkhill +49 more
TL;DR: It is proposed that variable horizontal gene acquisition by B. pseudomallei is an important feature of recent genetic evolution and that this has resulted in a genetically diverse pathogenic species.
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Tularaemia: bioterrorism defence renews interest in Francisella tularensis
TL;DR: Francisella tularensis is a highly infectious aerosolizable intracellular pathogen that is capable of causing a debilitating or fatal disease with doses as low as 25 colony-forming units, and there is no licensed vaccine available.
Journal ArticleDOI
The complete genome sequence of Francisella tularensis, the causative agent of tularemia.
Pär Larsson,Petra C. F. Oyston,Patrick S. G. Chain,May C. Chu,Melanie Duffield,Hans-Henrik Fuxelius,Emilio Garcia,Greger Hälltorp,Daniel Johansson,Karen E. Isherwood,Peter D. Karp,Eva Larsson,Ying Liu,Stephen L. Michell,Joann L. Prior,Richard G. Prior,Stephanie Malfatti,Anders Sjöstedt,Kerstin Svensson,Nicholas R Thompson,Lisa M. Vergez,Jonathan Wagg,Brendan W. Wren,Luther E. Lindler,Siv G. E. Andersson,Mats Forsman,Richard W. Titball,Richard W. Titball +27 more
TL;DR: The complete genome sequence of a highly virulent isolate of F. tularensis is reported and an unexpectedly high proportion of disrupted pathways are found, explaining the fastidious nutritional requirements of the bacterium.
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Targeting the “Cytokine Storm” for Therapeutic Benefit
TL;DR: This work reviews some of the current candidates for treatment of cytokine storms and compares them to more traditional therapeutic candidates that target the pathogen rather than the host response.