Emilio Carbone

TL;DR: Evidence is presented for a new type of Ca channel with time- and voltage-dependent properties which is probably responsible for the inactivation behaviour of the Ca conductance and coexists in isolated membrane patches with the more common Ca channel4 which shows a considerably shorter average life time and smaller currents.

TL;DR: No correlation between Ca2+ current amplitudes and activation‐inactivation kinetics was found, suggesting that the reaction rates which control these processes are not dependent on Ca2+, and the current was studied more precisely over a wider potential range.

TL;DR: The properties of this low voltage-activated and fully inactivating Ca current suggest it is the same as the inward current that has been postulated in several central neurons (Llinas, R., and Y. Yarom, 1981, J. Physiol.

TL;DR: Single-channel current recording in outside-out membrane patches revealed that a low membrane potentials dopamine and noradrenaline reversibly reduced single Ca-channel activity, which supports the view that in sensory and sympathetic neurons, both neurotransmitters affect the membrane conductance by modulating Ca permeability and not by activating catecholamine-specific channels able to carry transient outward currents.

TL;DR: Using voltage-clamped giant axons of the squid Loligo vulgaris, a polypeptide is identified in the venom of the scorpion Centruroides noxius Hoffmann that specifically depresses the peak permeability of K+ channels without affecting their voltage-dependent open–close kinetics.