L
Lourival D. Possani
Researcher at National Autonomous University of Mexico
Publications - 418
Citations - 16688
Lourival D. Possani is an academic researcher from National Autonomous University of Mexico. The author has contributed to research in topics: Venom & Scorpion toxin. The author has an hindex of 65, co-authored 406 publications receiving 15493 citations. Previous affiliations of Lourival D. Possani include Karolinska Institutet & Saint Louis University.
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Journal ArticleDOI
Scorpion toxins specific for Na+-channels.
TL;DR: A classification containing 10 different groups of toxins is proposed in this review, based on functional and structural features of the known toxins, and the limited success obtained in the search for the site through which these peptides bind to the channels.
Journal ArticleDOI
A unified nomenclature for short-chain peptides isolated from scorpion venoms: alpha-KTx molecular subfamilies.
Jan Tytgat,K. George Chandy,Maria L. Garcia,George A. Gutman,Marie-France Martin-Eauclaire,Jurg van der Walt,Lourival D. Possani +6 more
TL;DR: In this paper, the classification of K + channel blocking peptides belonging to family 2 peptides and comprising 30-40 amino acids linked by three or four disulfide bridges is discussed.
Journal Article
A unified nomenclature for short chain peptides isolated from scorpion venom: alpha-KTx molecular subfamilies
Jan Tytgat,KG Chandy,Maria L. Garcia,George A. Gutman,Marie-France Martin-Eauclaire,JJ van der Walt,Lourival D. Possani +6 more
TL;DR: This article describes the classification of K+-channel-blocking peptides belonging to family 2 peptides and comprising 30-40 amino acids linked by three or four disulfide bridges, and provides evidence for the existence of 12 molecular subfamilies, named alpha-KTx1-12, containing 49 different peptides.
Journal ArticleDOI
Current views on scorpion toxins specific for K+-channels.
TL;DR: The evolutionary tree indicates that several clusters of divergent peptides show preference for specific subtypes of channels, and four different interacting modes were identified to exist between scorpion toxins and the various sub types of K+-channels.
Journal ArticleDOI
Overview of scorpion toxins specific for Na+ channels and related peptides: biodiversity, structure-function relationships and evolution.
TL;DR: A critical view on problems associated with the study of these scorpion peptides is presented, drawing special attention to the points that need revision and to the subjects under intensive research at this moment, regarding scorpion toxins specific for Na(+) channels and the other related long-chain peptides recently described.