Emily S. Perotti

TL;DR: In this article, a high-throughput autoantibody discovery technique known as rapid extracellular antigen profiling was used to screen a cohort of 194 individuals infected with SARS-CoV-2, comprising 172 patients with COVID-19 and 22 health care workers with mild disease or asymptomatic infection, for auto-antibodies against 2,770 proteins (members of the exoproteome).

TL;DR: It is established that these autoantibodies perturb immune function and impair virological control by inhibiting immunoreceptor signaling and by altering peripheral immune cell composition, and found that murine surrogates of these autoantsibodies exacerbate disease severity in a mouse model of SARS-CoV-2 infection.

TL;DR: Analysis of circulating immune mediators and various hormones revealed pronounced differences, with levels of cortisol being uniformly lower among participants with Long COVID relative to matched control groups, and integration of immune phenotyping data into unbiased machine learning models identified significant distinguishing features critical in accurate classification of LongCOVID.