Mary E. Petrone

TL;DR: Investigators report that saliva specimens and nasopharyngeal swab specimens had similar sensitivity in the detection of SARS-CoV-2 Infection.

TL;DR: Comparisons of RT–qPCR analytical efficiency and sensitivity show that all primer–probe sets can be used to detect SARS-CoV-2 at 500 viral RNA copies per reaction.

TL;DR: In this article, a high-throughput autoantibody discovery technique known as rapid extracellular antigen profiling was used to screen a cohort of 194 individuals infected with SARS-CoV-2, comprising 172 patients with COVID-19 and 22 health care workers with mild disease or asymptomatic infection, for auto-antibodies against 2,770 proteins (members of the exoproteome).

TL;DR: It is shown that early SARS-CoV-2 transmission in Connecticut was likely driven by domestic introductions, and the risk of domestic importation to Connecticut exceeded that of international importation by mid-March regardless of the estimated effects of federal travel restrictions.

TL;DR: It is established that these autoantibodies perturb immune function and impair virological control by inhibiting immunoreceptor signaling and by altering peripheral immune cell composition, and found that murine surrogates of these autoantsibodies exacerbate disease severity in a mouse model of SARS-CoV-2 infection.