E
Emmanuel L. Gautier
Researcher at University of Paris
Publications - 73
Citations - 10512
Emmanuel L. Gautier is an academic researcher from University of Paris. The author has contributed to research in topics: Macrophage & Inflammation. The author has an hindex of 35, co-authored 64 publications receiving 8725 citations. Previous affiliations of Emmanuel L. Gautier include Institute of Chartered Accountants of Nigeria & Washington University in St. Louis.
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Journal ArticleDOI
Lysosomal Cholesterol Hydrolysis Couples Efferocytosis To Anti-Inflammatory Oxysterol Production
Stoyan Ivanov,Manon Viaud,Nemanja Vujic,Madalina Duta-Mare,Isabelle Dugail,Isabelle Hainault,Christian Stehlik,Sandrine Marchetti,Laurent Boyer,Rodolphe Guinamard,Fabienne Foufelle,Andrea E. Bochem,Kees Hovingh,Edward B. Thorp,Emmanuel L. Gautier,Dagmar Kratky,Laurent Yvan-Charvet +16 more
Journal Article
Abstract 344: Bcl-x Inactivation in Macrophages Accelerates Progression of Advanced Atherosclerotic Lesions in Apoe-/- Mice
Philippe Lesnik,Virginie Deswaerte,Emmanuel L. Gautier,Flora Saint-Charles,John Pirault,Edmund B. Rucker,Sophie Béliard,John Chapman,Wendy Jessup,Thierry Huby,Andrew I Shearn +10 more
TL;DR: In this article, Bcl-x deficiency in macrophages increased susceptibility to apoptosis, resulting in the depletion of tissue macrophage in vivo, including its major pool, Kuppfer cells in the liver.
Journal ArticleDOI
Targeted invalidation of SR-B1 in macrophages reduces macrophage apoptosis and accelerates atherosclerosis.
Lauriane Galle-Treger,Martine Moreau,Raphaëlle Ballaire,Lucie Poupel,Thomas Huby,Emanuele Sasso,Fulvia Troise,Francesco Potì,Philippe Lesnik,Wilfried Le Goff,Emmanuel L. Gautier,Thierry Huby +11 more
TL;DR: Macrophage SR-B1 plays a role in plaque growth by controlling macrophage apoptosis in an AIM-dependent manner and it is demonstrated that macrophages were protected from FC-induced apoptosis by AIM.
Journal ArticleDOI
Macrophage Origin, Metabolic Reprogramming and IL-1 Signaling: Promises and Pitfalls in Lung Cancer.
TL;DR: The current understanding of the bridge between TAM metabolism, IL-1β signaling, and effector functions in lung adenocarcinoma is reviewed and the challenges to successfully incorporating these pathways into current anticancer regimens are addressed.
Journal ArticleDOI
Promoting macrophage survival delays progression of pre-existing atherosclerotic lesions through macrophage-derived apoE
Laura Bouchareychas,Laura Bouchareychas,John Pirault,John Pirault,Flora Saint-Charles,Flora Saint-Charles,Virginie Deswaerte,Virginie Deswaerte,Tiphaine Le Roy,Tiphaine Le Roy,Wendy Jessup,Philippe Giral,Philippe Giral,Wilfried Le Goff,Wilfried Le Goff,Wilfried Le Goff,Thierry Huby,Thierry Huby,Thierry Huby,Emmanuel L. Gautier,Emmanuel L. Gautier,Emmanuel L. Gautier,Philippe Lesnik,Philippe Lesnik,Philippe Lesnik +24 more
TL;DR: Data show that promoting macrophage survival provides a supplemental source of apoE, which hinders pre-existing plaque progression, and highlighted macrophages-derived apOE as key in both the regulation of plasma and tissue cholesterol levels and the progression of pre- existing lesion.