Emran Bin Yunus

TL;DR: Presenting syndromes in severe malaria depend on age, although the incidence and the strong prognostic significance of coma and acidosis are similar at all ages, suggesting age is an independent risk factor for a fatal outcome of the disease.

TL;DR: If patients with severe malaria cannot be treated orally and access to injections will take several hours, a single inexpensive artesunate suppository at the time of referral substantially reduces the risk of death or permanent disability.

TL;DR: LAMP enables molecular diagnosis of falciparum malaria in settings with limited technical resources but will need further optimization, in contrast with a higher accuracy reported in an earlier study comparing LAMP with a non-validated PCR method.

TL;DR: Patients with a CAM score <2 at hospital admission may be safely treated in a general ward, provided that renal function can be monitored, and the model found that mortality increased steadily with increasing score.

TL;DR: Systemic oxidative stress is increased in severe malaria, and treatment with NAC had no effect on outcome in patients with severe falciparum malaria in this setting.