E
Enzo Lalli
Researcher at Centre national de la recherche scientifique
Publications - 158
Citations - 8594
Enzo Lalli is an academic researcher from Centre national de la recherche scientifique. The author has contributed to research in topics: Adrenal cortex & Adrenocortical carcinoma. The author has an hindex of 46, co-authored 150 publications receiving 7983 citations. Previous affiliations of Enzo Lalli include University of Nice Sophia Antipolis & French Institute of Health and Medical Research.
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An unusual member of the nuclear hormone receptor superfamily responsible for X-linked adrenal hypoplasia congenita
Elena Zanaria,Françoise Muscatelli,Barbara Bardoni,Tim M. Strom,S Guioli,Weiwen Guo,Enzo Lalli,Claudio Moser,Ann P. Walker,Edward R. B. McCabe,Thomas Meitinger,Anthony P. Monaco,Paolo Sassone-Corsi,Giovanna Camerino,Giovanna Camerino +14 more
TL;DR: The gene responsible for the disease, DAX-1, which is deleted or mutated in X-linked adrenal hypoplasia patients, is isolated and encodes a new member of the nuclear hormone receptor super-family displaying a novel DNA-binding domain.
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Inducibility and negative autoregulation of CREM: an alternative promoter directs the expression of ICER, an early response repressor.
TL;DR: It is reported that CREM is unique within the family of cAMP-responsive promoter element (CRE)-binding factors since it is inducible by activation of the cAMP signaling pathway and constituting a negative autoregulatory loop.
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DNA binding and transcriptional repression by DAX-1 blocks steroidogenesis
TL;DR: In vitro and in vivo evidence is provided that DAX-1 binds DNA and acts as a powerful transcriptional repressor of StAR gene expression, leading to a drastic decrease in steroid production.
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Signal transduction and gene regulation: the nuclear response to cAMP.
Enzo Lalli,Paolo Sassone-Corsi +1 more
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Steroidogenic factor 1 and Dax-1 colocalize in multiple cell lineages: potential links in endocrine development.
Yoi Ikeda,Amanda Swain,Thomas Weber,Kathryn E. Hentges,Elena Zanaria,Enzo Lalli,Katherine Tamai,Paolo Sassone-Corsi,Robin Lovell-Badge,Giovanna Camerino,Keith L. Parker +10 more
TL;DR: The striking colocalization of SF-1 and Dax-1 supports the model that they are intimately linked in a common pathway of endocrine development.