E
Eri Kikkawa
Researcher at Tokai University
Publications - 30
Citations - 1107
Eri Kikkawa is an academic researcher from Tokai University. The author has contributed to research in topics: Gene & Human leukocyte antigen. The author has an hindex of 15, co-authored 27 publications receiving 1047 citations.
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Journal ArticleDOI
High-throughput DNA typing of HLA-A, -B, -C, and -DRB1 loci by a PCR-SSOP-Luminex method in the Japanese population.
Yoshiki Itoh,Nobuhisa Mizuki,Tsuyako Shimada,Fumihiro Azuma,Mitsuo Itakura,Koichi Kashiwase,Eri Kikkawa,Jerzy K. Kulski,Masahiro Satake,Hidetoshi Inoko +9 more
TL;DR: The PCR–SSOP–Luminex method provides a simple, accurate, and rapid approach toward multiplex genotyping of HLA alleles to the four-digit or higher level of resolution in the Japanese population.
Journal ArticleDOI
Molecular dynamics of MHC genesis unraveled by sequence analysis of the 1,796,938-bp HLA class I region.
Takashi Shiina,Gen Tamiya,Akira Oka,Nobusada Takishima,Tetsushi Yamagata,Eri Kikkawa,Kyoko Iwata,M. Tomizawa,Noriko Okuaki,Yuko Kuwano,Koji Watanabe,Yasuhito Fukuzumi,Shoko Itakura,Chiyo Sugawara,Ayako Ono,Masaaki Yamazaki,Hiroyuki Tashiro,Asako Ando,Toshimichi Ikemura,Eiichi Soeda,Minoru Kimura,Seiamak Bahram,Hidetoshi Inoko +22 more
TL;DR: This work reports the continuous 1,796,938-bp genomic sequence of the HLA class I region, linking genes between MICB and HLA-F, and establishes that the repeated duplication and subsequent diversification of a minimal building block engendered the present-day MHC.
Journal ArticleDOI
Super high resolution for single molecule‐sequence‐based typing of classical HLA loci at the 8‐digit level using next generation sequencers
Takashi Shiina,Shingo Suzuki,Yuki Ozaki,H Taira,Eri Kikkawa,Atsuko Shigenari,Akira Oka,Takeji Umemura,Satoru Joshita,O Takahashi,Y Hayashi,M Paumen,Yoshihiko Katsuyama,Shigeki Mitsunaga,Masao Ota,Jerzy K. Kulski,Hidetoshi Inoko +16 more
TL;DR: The SS-SBT method described here is a superior and effective HLA DNA typing method to efficiently detect new HLA alleles and null alleles without ambiguity.
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Rapid Evolution of Major Histocompatibility Complex Class I Genes in Primates Generates New Disease Alleles in Humans via Hitchhiking Diversity
Takashi Shiina,Masao Ota,Sayoko Shimizu,Yoshihiko Katsuyama,Nami Hashimoto,Miwa Takasu,Tatsuya Anzai,Jerzy K. Kulski,Jerzy K. Kulski,Eri Kikkawa,Taeko Naruse,Natsuki Kimura,Kazuyo Yanagiya,Atsushi Watanabe,Kazuyoshi Hosomichi,Sakae Kohara,Chie Iwamoto,Yumi Umehara,Alice Meyer,Valérie Wanner,Kazumi Sano,Cécile Macquin,Kazuho Ikeo,Katsushi Tokunaga,Takashi Gojobori,Hidetoshi Inoko,Seiamak Bahram +26 more
TL;DR: The overrepresentation of a fraction of these hvSNV (hv1SNV) along with hsSNV, as compared to those that appear to have been maintained throughout primate evolution, tends to establish that the majority of the MHC polymorphism is de novo (species specific).
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Nucleotide sequencing analysis of the 146-kilobase segment around the IkBL and MICA genes at the centromeric end of the HLA class I region
Takashi Shiina,Gen Tamiya,Akira Oka,Tetsushi Yamagata,Naomi Yamagata,Eri Kikkawa,Kaori Goto,Nobuhisa Mizuki,Koji Watanabe,Yasuhito Fukuzumi,Susumu Taguchi,Chiyo Sugawara,Ayako Ono,Lei Chen,Masaaki Yamazaki,Hiroyuki Tashiro,Asako Ando,Toshimichi Ikemura,Minoru Kimura,Hidetoshi Inoko +19 more
TL;DR: To elucidate the complete gene structure and to identify new genes involved in the development of HLA class I antigen-associated diseases in the class I region of the human major histocompatibility complex on chromosome 6, a YAC clone covering the 146-kb segment around the IkBL and MICA loci was isolated.