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Eric Bachman
Researcher at Alexion Pharmaceuticals
Publications - 12
Citations - 1042
Eric Bachman is an academic researcher from Alexion Pharmaceuticals. The author has contributed to research in topics: Hepcidin & Testosterone (patch). The author has an hindex of 9, co-authored 11 publications receiving 819 citations. Previous affiliations of Eric Bachman include Boston University & Harvard University.
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Journal ArticleDOI
Testosterone Induces Erythrocytosis via Increased Erythropoietin and Suppressed Hepcidin: Evidence for a New Erythropoietin/Hemoglobin Set Point
Eric Bachman,Thomas G. Travison,Shehzad Basaria,Maithili N. Davda,Wen Guo,Michelle Li,John Connor Westfall,Harold Bae,Victor R. Gordeuk,Shalender Bhasin +9 more
TL;DR: Testosterone-induced increase in hemoglobin and hematocrit is associated with stimulation of EPO and reduced ferritin and hepcidin concentrations, suggesting a new set point for erythropoiesis.
Journal ArticleDOI
Testosterone suppresses hepcidin in men: a potential mechanism for testosterone-induced erythrocytosis.
Eric Bachman,Rui Feng,Thomas G. Travison,Michelle Li,Gordana Olbina,Vaughn Ostland,Jagadish Ulloor,Anqi Zhang,Shehzad Basaria,Tomas Ganz,Mark Westerman,Shalender Bhasin +11 more
TL;DR: Hepcidin suppression in response to testosterone administration was dose-dependent in older men and more pronounced than in young men, and this corresponded to a greater rise in hemoglobin in Older men.
Journal ArticleDOI
Ravulizumab (ALXN1210) vs eculizumab in C5-inhibitor-experienced adult patients with PNH: the 302 study.
Austin G. Kulasekararaj,Anita J. Hill,Scott T. Rottinghaus,Saskia Langemeijer,Richard A. Wells,F. Ataulfo Gonzalez-Fernandez,Anna Gaya,Jong Wook Lee,Emilio Ojeda Gutierrez,Caroline I. Piatek,Jeff Szer,Antonio M. Risitano,Shinji Nakao,Eric Bachman,Lori Shafner,Andrew I. Damokosh,Stephan Ortiz,Alexander Röth,Régis Peffault de Latour +18 more
TL;DR: Patients with PNH may be safely and effectively switched from labeled-dose eculizumab administered every 2 weeks to ravulizumabs administered every 8 weeks, and no meningococcal infections or discontinuations due to adverse events occurred.
Journal ArticleDOI
Testosterone administration inhibits hepcidin transcription and is associated with increased iron incorporation into red blood cells
Wen Guo,Eric Bachman,Michelle Li,Cindy N. Roy,Jerzy S. Blusztajn,Siu Wong,Stephen Y. Chan,Carlo Serra,Ravi Jasuja,Thomas G. Travison,Martina U. Muckenthaler,Elizabeta Nemeth,Shalender Bhasin +12 more
TL;DR: Testosterone inhibits hepcidin transcription through its interaction with BMP/Smad signaling and is associated with increased iron incorporation into red blood cells.
Journal ArticleDOI
Effects of testosterone replacement in men with opioid-induced androgen deficiency: a randomized controlled trial.
Shehzad Basaria,Thomas G. Travison,Thomas G. Travison,Daniel P. Alford,Philip E. Knapp,Kjersten Teeter,Christine Cahalan,Richard Eder,Kishore M. Lakshman,Eric Bachman,George Mensing,Marc O. Martel,Dillon Le,Helene Stroh,Shalender Bhasin,Ajay D. Wasan,Robert R. Edwards +16 more
TL;DR: In men with opioid-induced androgen deficiency, testosterone administration improved pain sensitivity, sexual desire, body composition, and aspects of quality of life.