M
Martina U. Muckenthaler
Researcher at Heidelberg University
Publications - 247
Citations - 19958
Martina U. Muckenthaler is an academic researcher from Heidelberg University. The author has contributed to research in topics: Hepcidin & Ferroportin. The author has an hindex of 63, co-authored 219 publications receiving 17431 citations. Previous affiliations of Martina U. Muckenthaler include University of Pennsylvania & Boston Children's Hospital.
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MicroRNA-21 contributes to myocardial disease by stimulating MAP kinase signalling in fibroblasts
Thomas Thum,Carina Gross,Jan Fiedler,Thomas Fischer,Stephan Kissler,Markus Bussen,Paolo Galuppo,Steffen Just,Wolfgang Rottbauer,Stefan Frantz,Mirco Castoldi,Jürgen Soutschek,Victor Koteliansky,Andreas Rosenwald,M. Albert Basson,Jonathan D. Licht,John T. R. Pena,Sara H. Rouhanifard,Martina U. Muckenthaler,Thomas Tuschl,Gail R. Martin,Johann Bauersachs,Stefan Engelhardt,Stefan Engelhardt +23 more
TL;DR: It is shown that microRNA-21 regulates the ERK–MAP kinase signalling pathway in cardiac fibroblasts, which has impacts on global cardiac structure and function and confirms miR-21 as a disease target in heart failure and establishes the therapeutic efficacy of microRNA therapeutic intervention in a cardiovascular disease setting.
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Balancing Acts: Molecular Control of Mammalian Iron Metabolism
TL;DR: The study of iron biology has provided novel insights into gene regulation and unveiled remarkable links to the immune system.
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Two to Tango: Regulation of Mammalian Iron Metabolism
TL;DR: How the two distinct systems of iron metabolism function and how they "tango" together in a coordinated manner are described are described.
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A Red Carpet for Iron Metabolism
TL;DR: These impressive numbers illustrate why the making and breaking of RBCs is at the heart of iron physiology, providing an ideal context to discuss recent progress in understanding the systemic and cellular mechanisms that underlie the regulation of iron homeostasis and its disorders.
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Systemic Iron Homeostasis and the Iron-Responsive Element/Iron-Regulatory Protein (IRE/IRP) Regulatory Network
TL;DR: This work reviews recent data that uncover the importance of the cellular iron-responsive element/iron-regulatory protein (IRE/IRP) regulatory network in systemic iron homeostasis and how it communicates with the hepcidin/ferroportin system to connect the control networks for systemic and cellular iron balance.