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Eric D. Lynch
Researcher at University of Washington
Publications - 23
Citations - 3074
Eric D. Lynch is an academic researcher from University of Washington. The author has contributed to research in topics: Gene & Gene mapping. The author has an hindex of 19, co-authored 23 publications receiving 2967 citations. Previous affiliations of Eric D. Lynch include University of Pennsylvania & University of Michigan.
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Journal ArticleDOI
Confirmation of BRCA1 by analysis of germline mutations linked to breast and ovarian cancer in ten families
Lori Friedman,Elizabeth A. Ostermeyer,Csilla Szabo,Patrick Dowd,Eric D. Lynch,Sarah Rowell,Mary Claire King +6 more
TL;DR: Genetic evidence supporting the identity of the candidate gene for BRCA1 through the characterization of germline mutations in 63 breast cancer patients and 10 ovarian cancer patients in ten families with cancer linked to chromosome 17q21 is provided.
Journal ArticleDOI
Nonsyndromic Deafness DFNA1 Associated with Mutation of a Human Homolog of the Drosophila Gene diaphanous
Eric D. Lynch,Ming K. Lee,Ming K. Lee,Jan E. Morrow,Jan E. Morrow,Piri Welcsh,Piri Welcsh,Pedro E. Leon,Pedro E. Leon,Mary Claire King,Mary Claire King +10 more
TL;DR: The gene responsible for autosomal dominant, fully penetrant, nonsyndromic sensorineural progressive hearing loss in a large Costa Rican kindred was previously localized to chromosome 5q31 and named DFNA1.
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Mutation in transcription factor POU4F3 associated with inherited progressive hearing loss in humans.
Oz Vahava,Robert J. Morell,Eric D. Lynch,Sigal Weiss,Marjory E. Kagan,Nadav Ahituv,Jan E. Morrow,Ming K. Lee,Anne B. Skvorak,Cynthia C. Morton,Anat Blumenfeld,Moshe Frydman,Thomas B. Friedman,Mary Claire King,Karen B. Avraham +14 more
TL;DR: The molecular basis for autosomal dominant progressive nonsyndromic hearing loss in an Israeli Jewish family, Family H, has been determined and an 8-base pair deletion in the POU homeodomain of human POU4F3 was identified in Family H.
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PTEN methylation is associated with advanced stage and microsatellite instability in endometrial carcinoma.
Helga B. Salvesen,Helga B. Salvesen,Nicola MacDonald,Andy Ryan,Ian Jacobs,Eric D. Lynch,Lars A. Akslen,Soma Das +7 more
TL;DR: It is found that PTEN promoter methylation is relatively frequent in endometrial carcinoma and its association with metastatic disease and microsatellite instability implicates its importance in the development of this tumor type.
Journal ArticleDOI
Inherited Mutations in PTEN That Are Associated with Breast Cancer, Cowden Disease, and Juvenile Polyposis
Eric D. Lynch,Elizabeth A. Ostermeyer,Ming K. Lee,J. Fernando Arena,Hanlee P. Ji,Jamie L. Dann,Karen Swisshelm,David Suchard,Patrick MacLeod,Stener Kvinnsland,Bjørn Tore Gjertsen,Ketil Heimdal,Herb Lubs,Herb Lubs,Pål Møller,Mary Claire King +15 more
TL;DR: Germ-line PTEN mutations predispose to breast cancer in association with CD, although the signs of CD may be subtle, and mutant transcripts appeared unstable in RNA from normal tissues from three families.