D
Dimitre R. Simeonov
Researcher at University of California, San Francisco
Publications - 32
Citations - 2658
Dimitre R. Simeonov is an academic researcher from University of California, San Francisco. The author has contributed to research in topics: Enhancer & Immune system. The author has an hindex of 19, co-authored 30 publications receiving 1965 citations. Previous affiliations of Dimitre R. Simeonov include Rensselaer Polytechnic Institute & National Institutes of Health.
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Journal ArticleDOI
Generation of knock-in primary human T cells using Cas9 ribonucleoproteins.
Kathrin Schumann,Steven Lin,Eric Boyer,Dimitre R. Simeonov,Meena Subramaniam,Rachel E. Gate,Genevieve E. Haliburton,Chun Jimmie Ye,Jeffrey A. Bluestone,Jennifer A. Doudna,Alexander Marson,Alexander Marson +11 more
TL;DR: Efficient genome engineering in human CD4+ T cells using Cas9:single-guide RNA ribonucleoproteins (Cas9 RNPs) is reported, establishing Cas9 RNP technology for diverse experimental and therapeutic genome engineering applications in primary human T cells.
Journal ArticleDOI
Enhancer connectome in primary human cells identifies target genes of disease-associated DNA elements
Maxwell R. Mumbach,Ansuman T. Satpathy,Evan A. Boyle,Chao Dai,Benjamin G. Gowen,Seung Woo Cho,Michelle L.T. Nguyen,Adam J. Rubin,Jeffrey M. Granja,Katelynn R. Kazane,Yuning Wei,Trieu Nguyen,Peyton Greenside,M. Ryan Corces,Josh Tycko,Dimitre R. Simeonov,Nabeela Suliman,Rui Li,Jin Xu,Ryan A. Flynn,Anshul Kundaje,Paul A. Khavari,Alexander Marson,Alexander Marson,Jacob E. Corn,Thomas Quertermous,William J. Greenleaf,Howard Y. Chang +27 more
TL;DR: It is shown that H3K27ac HiChIP generates high-resolution contact maps of active enhancers and target genes in rare primary human T cell subtypes and coronary artery smooth muscle cells, providing a principled means of assigning molecular functions to autoimmune and cardiovascular disease risk variants.
Journal ArticleDOI
Revisiting IL-2: Biology and therapeutic prospects
TL;DR: It is established that IL-2 is essential for the maintenance of Foxp3+ regulatory T cells (Treg cells), and in its absence, there is a profound deficiency of Treg cells and resulting autoimmunity, and has dual and opposing functions.
Journal ArticleDOI
GRIN2A mutation and early‐onset epileptic encephalopathy: personalized therapy with memantine
Tyler Mark Pierson,Hongjie Yuan,Eric D. Marsh,Karin Fuentes-Fajardo,David R. Adams,Thomas C. Markello,Gretchen Golas,Dimitre R. Simeonov,Conisha Holloman,Anel Tankovic,Manish M. Karamchandani,John M. Schreiber,James C. Mullikin,Cynthia J. Tifft,Camilo Toro,Cornelius F. Boerkoel,Stephen F. Traynelis,William A Gahl +17 more
TL;DR: Techniques of modern translational medicine are employed to identify a disease‐causing mutation, analyze its altered behavior, and screen for therapeutic compounds to treat the proband.
Journal ArticleDOI
Discovery of stimulation-responsive immune enhancers with CRISPR activation
Dimitre R. Simeonov,Benjamin G. Gowen,Mandy Boontanrart,Theodore L. Roth,John D. Gagnon,Maxwell R. Mumbach,Ansuman T. Satpathy,Youjin Lee,Youjin Lee,Nicolas Bray,Alice Y. Chan,Dmytro Lituiev,Michelle L.T. Nguyen,Michelle L.T. Nguyen,Rachel E. Gate,Meena Subramaniam,Zhongmei Li,Zhongmei Li,Jonathan M. Woo,Jonathan M. Woo,Therese Mitros,Graham J. Ray,Gemma L. Curie,Nicki Naddaf,Julia S. Chu,Hong Ma,Eric Boyer,Eric Boyer,Frédéric Van Gool,Hailiang Huang,Hailiang Huang,Ruize Liu,Ruize Liu,Victoria Tobin,Victoria Tobin,Kathrin Schumann,Kathrin Schumann,Mark J. Daly,Mark J. Daly,Kyle Kai-How Farh,K. Mark Ansel,Chun Jimmie Ye,William J. Greenleaf,Mark S. Anderson,Jeffrey A. Bluestone,Howard Y. Chang,Jacob E. Corn,Alexander Marson +47 more
TL;DR: A discovery platform that can identify stimulus-responsive enhancers for a target gene independent of stimulus exposure is described and reveals how non-coding variation associated with human immune dysfunction alters context-specific gene programs.