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Eric Dale Jones
Researcher at Monash University, Parkville campus
Publications - 23
Citations - 390
Eric Dale Jones is an academic researcher from Monash University, Parkville campus. The author has contributed to research in topics: Prodrug & Integrase inhibitor. The author has an hindex of 11, co-authored 23 publications receiving 375 citations.
Papers
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Journal ArticleDOI
Small Molecule Inhibitors of the Ledgf Site of Human Immunodeficiency Virus Integrase Identified by Fragment Screening and Structure Based Design.
Thomas S. Peat,David Ian Rhodes,Nick Vandegraaff,Giang Thanh Le,Jessica A. Smith,Lisa Clark,Eric Dale Jones,Jonathan Coates,Neeranat Thienthong,Janet Newman,Olan Dolezal,Roger J. Mulder,John H. Ryan,G. Paul Savage,Craig L. Francis,John Deadman +15 more
TL;DR: The compounds identified represent a potential framework for the development of a new series of HIV integrase inhibitors that do not bind to the catalytic site of the enzyme.
Journal ArticleDOI
Structural basis for a new mechanism of inhibition of HIV-1 integrase identified by fragment screening and structure-based design
David Ian Rhodes,Thomas S. Peat,Nick Vandegraaff,Dharshini Jeevarajah,Giang Thanh Le,Eric Dale Jones,Jessica A. Smith,Jonathan Coates,Lisa Jane Winfield,Neeranat Thienthong,Janet Newman,Del Lucent,John H. Ryan,G. Paul Savage,Craig L. Francis,John Deadman +15 more
TL;DR: A new site in integrase is defined as a valid region for the structure-based design of allosteric integrase inhibitors, which has improved the activity of the initial fragments 45-fold and is used to develop these fragments into more potent novel enzyme inhibitors.
Patent
Integrase inhibitors 3
TL;DR: In this article, a method of treatment or prophylaxis of a viral infection in a subject comprising administering to said subject an effective amount of a compound of formula (I) or a pharmaceutically acceptable derivative, salt or prodrug thereof is presented.
Journal ArticleDOI
Design of a series of bicyclic HIV-1 integrase inhibitors. Part 1: Selection of the scaffold
Eric Dale Jones,Nick Vandegraaff,Giang Thanh Le,Neil Choi,William Issa,Katherine Macfarlane,Neeranat Thienthong,Lisa Jane Winfield,Jonathan Coates,Long Lu,Xinming Li,Xiao Feng,Changjiang Yu,David Ian Rhodes,John Deadman +14 more
TL;DR: HIV integrase inhibitors based on a novel bicyclic pyrimidinone core is presented, leading to optimization of the 6:6 core giving compound 48 with an EC(50) of 3 nM against wild type HIV infected T-cells.
Journal ArticleDOI
Examination of the Role of Intestinal Fatty Acid-Binding Protein in Drug Absorption Using a Parallel Artificial Membrane Permeability Assay
Tony Velkov,James Horne,Aisha Laguerre,Eric Dale Jones,Martin J. Scanlon,Christopher J.H. Porter +5 more
TL;DR: It is suggested that intracellular lipid-binding proteins such as I-FABP may enhance the membrane transport of lipophilic xenobiotics and facilitate drug access to the enterocyte cytoplasm and cy toplasmic organelles.