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Eric de La Fortelle
Researcher at Laboratory of Molecular Biology
Publications - 8
Citations - 3023
Eric de La Fortelle is an academic researcher from Laboratory of Molecular Biology. The author has contributed to research in topics: AP endonuclease & Binding site. The author has an hindex of 7, co-authored 8 publications receiving 2991 citations.
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Book ChapterDOI
[27] Maximum-likelihood heavy-atom parameter refinement for multiple isomorphous replacement and multiwavelength anomalous diffraction methods
TL;DR: This chapter discusses the maximum-likelihood heavy-atom parameter refinement for multiple isomorphous replacement (MIR) and multiwavelength anomalous diffraction (MAD) and its extension to probability distributions incorporating anomalousdiffraction effects, as well as measurement error and nonisomorphism.
Journal ArticleDOI
Crystal structures of two Sm protein complexes and their implications for the assembly of the spliceosomal snRNPs.
C. Kambach,S. Walke,Robert I. M. Young,Johanna M. Avis,Eric de La Fortelle,Veronica A. Raker,Reinhard Lührmann,Jade Li,Kiyoshi Nagai +8 more
TL;DR: Crystal structures suggest that the seven Sm proteins could form a closed ring and the snRNAs may be bound in the positively charged central hole.
Journal ArticleDOI
The crystal structure of the human DNA repair endonuclease HAP1 suggests the recognition of extra‐helical deoxyribose at DNA abasic sites
Michael A. Gorman,Solange Moréra,Dominic G. Rothwell,Eric de La Fortelle,Clifford D. Mol,John A. Tainer,Ian D. Hickson,Paul S. Freemont +7 more
TL;DR: The HAP1 structure suggests a mechanism for AP site binding which involves the recognition of the deoxyribose moiety in an extra‐helical conformation, rather than a ‘flipped‐out’ base opposite the AP site.
Journal ArticleDOI
Crystal structure of the anti-fungal target N-myristoyl transferase.
Simon A. Weston,Roger Camble,Jeremy G. Colls,Gina Rosenbrock,Ian W. F. Taylor,Mark Egerton,Alec D. Tucker,Alec D. Tucker,Alan Tunnicliffe,Anil Mistry,Filippo Mancia,Filippo Mancia,Eric de La Fortelle,John J. Irwin,Gérard Bricogne,Richard A. Pauptit +15 more
TL;DR: The groove and pocket are the sites of substrate binding and the floor of the pocket is the catalytic center of N-myristoyl transferase, which has a novel α/β fold which shows internal twofold symmetry, which may be a result of gene duplication.
Journal ArticleDOI
Crystal structure of a fungal elicitor secreted by Phytophthora cryptogea, a member of a novel class of plant necrotic proteins
Guillaume Boissy,Eric de La Fortelle,Richard A. Kahn,Jean-Claude Huet,Gérard Bricogne,Jean-Claude Pernollet,Simone Brunie +6 more
TL;DR: The determination of the crystal structure of a member of the elicitin family may make it possible to separate the activity that causes leaf necrosis from that inducing systemic acquired resistance to pathogens, making it feasible to engineer a non-toxic elicitin that only elicits plant defences.