Eric Koncina

TL;DR: The results indicate that the capacity to form a functional NLRP3 inflammasome and secretion of IL-1β is limited to the microglial compartment in the mouse brain and microglia-dependent inflammaome activation can play an important role in the brain and especially in neuroinflammatory conditions.

TL;DR: The different molecular markers in clinical use for CRC are described, new markers that might become indispensable over the next years are highlighted, recently developed gene expression-based tests are discussed and the challenges in biomarker research are highlighted.

TL;DR: The hypoxia-autophagy-PKC-EZR signaling axis is established as a novel regulatory mechanism of TIC self-renewal and CRC progression and might represent a promising therapeutic strategy for cancer patients.

TL;DR: It is reported that during the early response of reactive gliosis, inflammation induces a conversion of mature astrocytes into neural progenitors via the re-expression of Oct4, and activation of the NF-κB pathway through TNF plays an important role in the dedifferentiation of astroCytes.

TL;DR: The observations indicate that α-synuclein inclusion formation is not the major driver in the early phases of PD-like neurodegeneration, but that diffusible, oligomeric α- synuclein species, which induce unusual microglial reactivity, play a key role in this process.