A
Alessandro Michelucci
Researcher at University of Luxembourg
Publications - 50
Citations - 2745
Alessandro Michelucci is an academic researcher from University of Luxembourg. The author has contributed to research in topics: Microglia & Medicine. The author has an hindex of 18, co-authored 41 publications receiving 1944 citations. Previous affiliations of Alessandro Michelucci include Centre national de la recherche scientifique & King's College London.
Papers
More filters
Journal ArticleDOI
Immune-responsive gene 1 protein links metabolism to immunity by catalyzing itaconic acid production
Alessandro Michelucci,Thekla Cordes,Jenny Ghelfi,Arnaud Pailot,Norbert Reiling,Oliver Goldmann,Tina M. Binz,Andre Wegner,Aravind Tallam,Antonio Rausell,Manuel Buttini,Carole L. Linster,Eva Medina,Rudi Balling,Karsten Hiller +14 more
TL;DR: It is shown that itaconic acid inhibits the growth of bacteria expressing isocitrate lyase, such as Salmonella enterica and Mycobacterium tuberculosis, and Irg1 gene silencing in macrophages resulted in significantly decreased intracellular itaconi acid levels as well as significantly reduced antimicrobial activity during bacterial infections.
Journal ArticleDOI
Characterization of the microglial phenotype under specific pro-inflammatory and anti-inflammatory conditions: Effects of oligomeric and fibrillar amyloid-β
TL;DR: In order to study the polarization induced by Abeta, microglia was stimulated with different forms of the peptide and found that the oligomeric Abeta is a stronger M1-inductor than the fibrillar form.
Journal ArticleDOI
Immunoresponsive Gene 1 and Itaconate Inhibit Succinate Dehydrogenase to Modulate Intracellular Succinate Levels.
Thekla Cordes,Martina Wallace,Alessandro Michelucci,Ajit S. Divakaruni,Sean C. Sapcariu,Carole Sousa,Haruhiko Koseki,Pedro Cabrales,Anne N. Murphy,Karsten Hiller,Christian M. Metallo +10 more
TL;DR: It is demonstrated that itaconate acts as an endogenous succinate dehydrogenase inhibitor to cause succinate accumulation and links the innate immune response and tricarboxylic acid metabolism to function of the electron transport chain.
Journal ArticleDOI
The Itaconate Pathway Is a Central Regulatory Node Linking Innate Immune Tolerance and Trained Immunity
Jorge Domínguez-Andrés,Boris Novakovic,Yang Li,Brendon P. Scicluna,Mark S. Gresnigt,Rob J.W. Arts,Marije Oosting,Simone J.C.F.M. Moorlag,Laszlo Groh,Jelle Zwaag,Rebecca M. Koch,Rob ter Horst,Leo A. B. Joosten,Cisca Wijmenga,Alessandro Michelucci,Tom van der Poll,Matthijs Kox,Peter Pickkers,Vinod Kumar,Vinod Kumar,Henk Stunnenberg,Mihai G. Netea +21 more
TL;DR: The role of itaconate was validated by IRG1 and SDH polymorphisms that modulate induction of tolerance and trained immunity in human monocytes, and the potential of β-glucan-induced trained immunity to revert immunoparalysis was highlighted.
Journal ArticleDOI
Single-cell transcriptomics reveals distinct inflammation-induced microglia signatures.
Carole Sousa,Anna Golebiewska,Suresh Poovathingal,Suresh Poovathingal,Tony Kaoma,Yolanda Pires-Afonso,Silvia Martina,Djalil Coowar,Francisco Azuaje,Alexander Skupin,Alexander Skupin,Rudi Balling,Knut Biber,Knut Biber,Simone P. Niclou,Alessandro Michelucci +15 more
TL;DR: It is shown that microglia isolated from LPS‐injected mice display a global downregulation of their homeostatic signature together with an upregulation of inflammatory genes, which greatly differ from neurodegenerative disease‐associated profiles.