Fabien Rodriguez

TL;DR: The aim of this review is to give a thorough overview of the commonly used fibroblast markers in the field and their various strengths and, more importantly, their weaknesses, as well as to highlight potential future avenues for CAF identification and targeting.

TL;DR: The hypoxia-autophagy-PKC-EZR signaling axis is established as a novel regulatory mechanism of TIC self-renewal and CRC progression and might represent a promising therapeutic strategy for cancer patients.

TL;DR: In this article , formate, a metabolite produced by the colorectal cancer associated bacterium Fusobacterium nucleatum, was shown to promote CRC development, and the authors identified formate as a gut derived oncometabolite that is relevant for CRC progression.

TL;DR: It is proposed that SC derived from fresh patient tumor tissue present interesting phenotypic features that may have clinical relevance for chemoresistance and disease relapse and therefore represent a valuable tool to test for new CRC-therapies that overcome drug resistance.

TL;DR: The data validate the concept that KRN encapsulated in PLGA-based particles can be used as delivery systems to activate iNKT cells in vitro and in vivo.